疫苗中抗生素使用安全问题的讨论

病毒性疫苗生产过程中,通常加入一定量抗生素以控制细胞培养过程中潜在的细菌、支原体污染.疫苗中的残余抗生素可能导致免疫接种后的儿童出现过敏反应.目前,国际上对疫苗中使用抗生素的安全问题予以高度关注.加强对人用疫苗生产过程中使用抗生素的管理和控制,对保证疫苗使用的安全性具有重要意义.

Discussion on the Safety of Antibiotics Used in Vaccines

In vaccine production antibiotics are usually added during cell culture to prevent bacterial or mycoplasma contamination. The residual antibiotics in vaccines may lead to hypersensitivity reactions in children who have received such vaccines. At present, the safety of use of antibiotics in vaccine production has created a worldwide concerns. It is of key importance to strengthen the management and control of the use of antibiotics in vaccine manufacture so as to ensure the safety use of vaccines.