| 子宫内膜癌p16／MTS1基因失活的研究 |
| |
| 引用本文： | 于莎莎,迟闺珠,朱章菱,肖白,王跃.子宫内膜癌p16／MTS1基因失活的研究[J].临床肿瘤学杂志,1998,3(4):10-12. |
| |
| 作者姓名： | 于莎莎 迟闺珠 朱章菱 肖白 王跃 |
| |
| 作者单位： | 首都医科大学附属红十字朝阳医院妇产科 |
| |
| 摘 要： | 目的:探讨p16/MTS1基因在子官内膜癌组织的表达及意义.方法:采用显微切割-聚合酶链反应方法,对29例子宫内膜癌组织和癌旁正常组织中p16/MTS1基因纯合缺失进行检测.并用Fisher精确检验的方法,对p16/MTS1基因纯合缺失与临床病理关系进行统计分析.结果:29例子宫内膜癌组织,p16/MTS1基因纯合缺失率为24.14%.Ⅰ期纯合缺失率为24.00%,Ⅱ期纯合缺失率为33.33%.结论:p16/MTS1基因纯合缺失与子宫内膜癌的发生有关.
|
| 关 键 词： | 子宫内膜癌 p16/MTS1 抑癌基因 |
Study on p16/MTSl Gene Inactivation in Carcinoma of Endometrium |
| |
| Yu shasha,Chi Guizhu,Zhu zhangling,et al..Study on p16/MTSl Gene Inactivation in Carcinoma of Endometrium[J].Chinese Clinical Oncology,1998,3(4):10-12. |
| |
| Authors: | Yu shasha Chi Guizhu Zhu zhangling |
| |
| Institution: | Yu shasha,Chi Guizhu,Zhu zhangling,et al. Chao yang Hospital,Beijing 100020 |
| |
| Abstract: | Purpose:To probe the expression of pl6/MTSl gene in carcinoma of endometrium. Methods:Homozygous dele-tion of p16/MTSl gene was examined by micro-cut PCR methods in tissue from tumor cells and by side with normal tissue from 29 cases of carcinoma of endometrium, The ralation for clinical and pathology was analysed with Fisher excatest. Results: 24. 14% homozygous deletion of p16/MTSl gene was found in carcinoma of endometrium. Conclusions:There was an relation-ship between homozygous deletion of p16/MTSl gene and occurring of carcinoma of endometrium. |
| |
| Keywords: | Carcinoma of endometrium p16/MTSl Gene |
| 本文献已被 CNKI 维普 等数据库收录！ |
|
