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阿霉素明胶微粒在骨肉瘤介入治疗中的临床应用
引用本文:徐义春,韩士英,廖威明,李佛保. 阿霉素明胶微粒在骨肉瘤介入治疗中的临床应用[J]. 临床肿瘤学杂志, 1998, 3(3): 12-15
作者姓名:徐义春  韩士英  廖威明  李佛保
作者单位:安徽省立医院(徐义春!230001合肥),中山医科大学一附院骨科(韩士英,廖威明,李佛保)
摘    要:目的:研制阿霉素明胶微粒并探讨其化学栓塞的可行性和临床、病理学变化特点.方法:用物理机械方法制出阿霉素明胶微粒,并用此对骨肉瘤患者进行化学栓塞,同时设立无水酒精栓塞组,直接截肢组和其进行对照.结果:(1)阿霉素明胶微粒进行化学栓塞,无明显不良反应;(2)阿霉素明胶微粒进行化学栓塞后,初期栓塞综合症较明显,二周后瘤体明显缩小,质地变硬,疼痛消失,皮温可降至正常,术中见瘤假包膜形成完整,出血明显减少,组织学示瘤体大部分坏死,伴纤维血管增生,肿瘤坏死率大于80%,以上变化和无水酒精栓塞组相比,无明显差异.但与直接截肢组差异显著.结论:阿霉素明胶微粒制作简单可行,进行化学栓塞效果明显,有利于保肢术开展.

关 键 词:骨肉瘤  阿霉素明胶微粒  介入治疗

Adriamycin gelatin microparticles for clinical application in the interventional therapy of ostcosarcoma
Xu Yichun,Han Shiyin,Li Fubao the orthopaedies. Adriamycin gelatin microparticles for clinical application in the interventional therapy of ostcosarcoma[J]. Chinese Clinical Oncology, 1998, 3(3): 12-15
Authors:Xu Yichun  Han Shiyin  Li Fubao the orthopaedies
Affiliation:Xu Yichun,Han Shiyin,Li Fubao the orthopaedies department of An Hui provincial hospital,He fei230001
Abstract:Purpose: Making adriamycin gelatin microparticles, probing the possibility of chcmocmbolization with the mi-croparticles and characters of clinical and histological changes after chemoembolization. Method: The physical and mechanical ways were adopted to make the micropaticles. The patients of osteasarcoma were given chemoembolization with it, compared with alcohol embolization group and amputation group. Results: (1) There were no severe side effects in using the microparticles for emboliation. (2) Early stage after emboliation with the microparticles, the embolization syndrome appeared obviously in the most cases, two weeks later. the volume of the tumors shrinked greatly, and the pain disappeared, skin temperature could drop to normal, in addition, the tunors become very hard. In operation the blood loss tremendously reduced, and thickened psendocap-sule of tumor were favorable to operation. The reactive fibrous proliferation with small mature vessels and massive necrosis of tu-mor cells were observed in the histological section, the average necrosis of tumor cells were more than 80%. The alcohol group had the similar all above mentioned changes, but significantly differences appeared in contrast to amputaion group. Conclusion: The self-making adriamycin gelatin microparticle is simple and practical, the microparticle is able to be used in the treatment of osteosarcoma embolization, which is favorable for limb-salvage operation.
Keywords:Osteosarcoma Adriamycin gelatin microparticles Interventional therapy.
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