| 门冬氨酸钾镁预防阿霉素心脏毒性的临床研究 |
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| 引用本文： | 陈樟树,陈曦,欧阳学农,程惠华,魏文.门冬氨酸钾镁预防阿霉素心脏毒性的临床研究[J].临床肿瘤学杂志,1998,3(4):26-28. |
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| 作者姓名： | 陈樟树 陈曦 欧阳学农 程惠华 魏文 |
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| 作者单位： | 南京军区福州总医院肿瘤科 |
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| 摘 要： | 目的:观察门冬氨酸钾镁(潘南金)对阿霉素所致心脏毒性的预防作用.方法:采用随机分组方法将53例入选病例分为门冬氨酸钾镁试验组(27例)与对照组(26例).治疗组于化疗前2天开始用门冬氨酸钾镁30～60ml加入5%葡萄糖液250～500ml中静滴,每日1次,直至化疗结束.对照组不用门冬氨酸钾镁,仅用普通药物.两组均以阿霉素为主联合化疗.结果:试验组患者化疗后无一例出现心脏毒性,对照组心脏毒性发生率为19.23%(5/26).结论:门冬氨酸钾镁对化疗中阿霉素所致心脏毒性有一定的预防作用.
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| 关 键 词： | 门冬氨酸钾镁 阿霉素 心脏毒性 |
The clinical studies on the preventive effect of potassium magnesium aspaptate on the cardio-toxicity induced by adriamycin |
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| Chen Zhangshu,Chen Xi,Ou ?Yang Xuenong,et al..The clinical studies on the preventive effect of potassium magnesium aspaptate on the cardio-toxicity induced by adriamycin[J].Chinese Clinical Oncology,1998,3(4):26-28. |
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| Authors: | Chen Zhangshu Chen Xi Ou ?Yang Xuenong |
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| Institution: | Chen Zhangshu,Chen Xi,Ou ?Yang Xuenong,et al. Cancer clinic institute,Fuzhou general hospital of PLA,Fuzhou 350025 |
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| Abstract: | Purpose:To study the preventive effect of potassium magnesium aspaptate(PMA) on the cardiotoxicity induced by adriamycin(ADM). Methods:53 patients with various cancer treated with adriamycin were divided at random into two groups: test group,27 cases,treated with PMA. Control group,26 cases,didn't inject PMA. Results:No one of the test group showed car-diotoxicity, but 5 cases in the control group showed electrocardiogram change. Conclusion:The results indicated that PMA had protective effect on the cardiotoxicity induced by ADM. |
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| Keywords: | Adriamycin Cardiotoxicity Potassium magnesium aspaptate |
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