积雪草苷类化合物对神经系统药理作用研究进展

积雪草总苷是积雪草的主要活性成分,其中的单体成分包括积雪草苷、羟基积雪草苷和积雪草酸等,在临床上主要用于治疗皮肤损伤,促进创面愈合以及瘢痕修复等。近年来发现积雪草苷类化学成分对神经系统也存在着多种药理活性,如抗抑郁、抗痴呆、对脊髓损伤以及脊髓神经细胞变性的保护、对抗脑缺血损伤以及镇痛、抗惊厥等。综述积雪草苷类化学成分对神经系统的药理作用研究进展,希望为该类化合物治疗神经系统疾病的研究与应用及新药开发提供理论依据。

Research progress on pharmacological effects of Centella asiatica compound on nervous system

Total triterpenes are the main active ingredients in Centella asiatica, in which the main monomer components are asiaticoside, madecassoside, asiatic acid, etc. The clinical treatment is mainly used in the treatment of skin injury, wound healing, scar repair, etc. In recent years, it has been found that total triterpenes of C. asiatica and its main monomer components have many pharmacological activities on the nervous system, such as anti-depression, anti-dementia, protection of spinal cord injury and spinal cord nerve cell degeneration, anti-brain ischemia injury, analgesia, anti-seizure, etc. This paper gives an overview of research progress of the pharmacological effects of the C. asiatica compound on the nervous system, hoping to provide a theoretical basis for the research and application of this compound in the treatment of nervous system diseases and new drug development.