代谢组学技术在中药药性理论研究中的应用概述

代谢组学作为系统生物学的重要组成部分,其研究思想与中医药研究思想的整体观相似。近几年,随着代谢组学技术的蓬勃发展,其在中药现代研究中的应用越来越广泛。通过对代谢组学起源、发展、研究内容及方法进行简要概述,并对其在中药药性理论,包括四气五味、升降沉浮、归经、有毒无毒、配伍、禁忌中的应用进行概述,初步分析并总结了代谢组学应用于中药药性理论研究所存在的问题及发展趋势。

Overview on application of metabonomics in study on Chinese materia medica property theory

Metabonomics as an important component of systems biology, the research idea is similar to the overall concept in the research of traditional Chinese medicine (TCM). In recent years, with the vigorous development of metabonomics, its application is more and more widely in modern research of Chinese material medica (CMM). In this paper, based on the introduction of origin, development, research content, and method of metabonomics, and at the same time its application on medicinal properties in TCM theory, including four Qi, five tastes, meridian entry, direction of medicinal actions (upward, downward, outward, and inward), toxicity, compatibility of medicines, and the contraindication of application, are summarized. The preliminary analysis and sums up of research problems and development trend on the metabonomics applying in TCM property theory have been brought forward.