小脑顶核电刺激对阿尔茨海默病磁共振波谱代谢物的影响

目的 采用MRS评价小脑顶核电刺激(FNS)对阿尔茨海默病(AD)患者后扣带回(PCC)代谢物的影响。方法 收集AD患者36例,随机分为治疗组和安慰组,各18例。治疗组给予小脑FNS治疗。治疗前、后采用MRS评估PCC代谢产物N-乙酰天门冬氨酸(NAA)/肌酸(Cr)值、肌醇(mI)/Cr值。比较两组治疗前、后代谢物的差异。结果 治疗组治疗后NAA/Cr值较治疗前轻度升高,但差异无统计学意义(P>0.05),mI/Cr值较治疗前降低,差异有统计学意义(t=-2.502,P<0.05);治疗后治疗组NAA/Cr值较安慰组升高,mI/Cr值降低,差异均有统计学意义(t=4.176、-4.987,P均<0.05)。结论 FNS治疗后AD大脑代谢物发生了变化,MRS可作为观察AD的客观辅助手段。

Influence of fastigial nucleus electrostimulation on metabolites for magnetic resonance spectroscopy in Alzheimer disease

Objective To assess the metabolite alteration of posterior cingulated cortex (PCC) in Alzheimer disease (AD) patients after therapy of fastigial nucleus electrostimulation (FNS) with MRS.Methods Thirty-six AD patients were randomly divided into treatment group and control group (each n=18).FNS was used to the treatment group.The ratios of N-Acetyl L-Aspartic acid (NAA)/Creatine (Cr) and Myo-inositol (mI)/Cr of PCC were assessed with MRS.The differences of metabolites in two groups before and after treatment were compared.Results Post-therapeutic ratio of NAA/Cr in treatment group increased slightly (P>0.05),mI/Cr was lower than the pre-therapeutic (t=-2.502,P<0.05).Compared with control group,NAA/Cr in treatment group increased,mI/Cr decreased,which were statistically significant differences (t=4.176,-4.987,all P<0.05).Conclusion The brain metabolites are altered in patients with AD after FNS.MRS is a useful and objective tool for observing AD.