银杏叶提取物对糖尿病视网膜病变的临床疗效评价

目的：探讨银杏叶提取物对轻中度非增生期糖尿病视网膜病变的临床疗效。方法：采用随机对照试验，将轻中度非增生期糖尿病视网膜病变患者80例150眼随机分为对照组和治疗组，治疗组41例78眼，对照组39例72眼。对照组给予拜阿司匹林肠溶片100mg，口服，1次／d。在上述治疗的基础上，治疗组患者加用银杏叶酊2 mL，口服，3次／d 进行干预。6 mo后，观察并分析两组患者视神经病变的总体疗效、视力、视野平均缺损、眼底荧光血管造影结果、血脂水平、血小板聚集率及血小板粘附率的改善情况。结果：治疗后，治疗组患者视网膜病变的总有效率为75．6％，显著高于对照组58．7％（ Z ＝2．6002， P ＝0．0047）；治疗组患者的视力显著提高，和视野平均缺损显著减少，差异均有统计学意义（t＝－2．01，P＝0．0477；t＝4．06，P＝0．0001）；治疗组患者的视网膜微血管瘤数、出血面积均显著减少，差异均有统计学意义（ t＝7．86，P ＜0．01；t＝3．13，P＝0．0024）；治疗组患者的血清总胆固醇、甘油三脂、低密度脂蛋白胆固醇水平均下降，高密度脂蛋白胆固醇升高，差异有统计学意义（t＝2．25，P＝0．0270；t＝3．41，P＝0．0010；t＝3．34， P＝0．0013；t＝3．76， P＝0．0003；t＝－3．30，P＝0．0014）；治疗组患者的血小板聚集率和血小板粘附率均下降，差异均有统计学意义（t＝4．31，P ＜0．01；t＝4．93，P ＜0．01）。结论：银杏叶提取物对轻中度非增生期糖尿病视网膜病变具有确切疗效。

Clinical evaluation of Ginkgo biloba extract for diabetic retinopathy

AIM:To evaluate the clinical efficacy of Ginkgo biloba extract(GBE)for the patients with mild or moderate non-proliferative diabetic retinopathy(NPDR).

METHODS: Randomized controlled study. A total of 80 patients(150 eyes)with mild or moderate NPDR were divided into two groups: the control group(39 patients with 72 eyes)and the treatment group(41 patients with 78 eyes). Patients in the control group were given 100mg enteric-coated aspirin tablets, orally, once per day. Based on the above treatment, the treated group was added with GBT 2mL, orally, three times per day. Patients were followed up for 6mo, and the overall curative effect, visual acuity, visual field mean defect, the result of fundus fluorescein angiography, serum lipid levels, platelet aggregation rate and platelet adhesion rate were measured and evaluated.

RESULTS: After treatments, the total effective rate in the treatment group was 75.6% and significantly higher than that(58.7%)in the control group(Z=2.6002, P=0.0047). Compared with the control group, the treatment group was found to have higher visual acuity and less visual field mean defect significantly(t=-2.01,P=0.0477; t=4.06,P=0.0001); the numbers of retinal micro-aneurysms and areas of retinal hemorrhage significantly decreased(t=7.86,P<0.01; t=3.13,P=0.0024); the serum total cholesterol, triglycerides, low-density lipoprotein cholesterol in treatment group significantly decreased, the high-density lipoprotein cholesterol increased(t=2.25,P=0.0270; t=3.41,P=0.0010; t=3.34,P=0.0013; t=3.76,P=0.0003; t=-3.30,P=0.0014); platelet aggregation rate and platelet adhesion rate were significantly lower(t=4.31,P<0.01; t=4.93,P<0.01).

CONCLUSION: The results show that GBT for treatment of mild and moderate NPDR has a definite effect.