| 阿托伐他汀降低急性冠脉综合征患者外周血CD_(14)~+单核细胞表面TLR4的表达 |
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| 引用本文： | 牛楠,曲鹏,徐丹,崔颖,丁彦春,王虹艳,朱宁,陈海英.阿托伐他汀降低急性冠脉综合征患者外周血CD_(14)~+单核细胞表面TLR4的表达[J].高血压杂志,2008(5). |
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| 作者姓名： | 牛楠 曲鹏 徐丹 崔颖 丁彦春 王虹艳 朱宁 陈海英 |
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| 作者单位： | 大连医科大学附属二院心血管内科;北京丰台区南苑医院内科; |
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| 摘 要： | 目的 Toll 样受体4(TLR4)的激活与动脉粥样斑块的进展及斑块的不稳定导致临床并发症的发生有关。他汀类调脂药物临床获益可能与其调脂以外的作用尤其是抗炎作用有关,但抗炎作用的确切机制目前还不清楚。推测其抗炎作用可能是通过抑制 TLR4炎症信号通路起作用的。方法入选者为健康志愿者(n=22)及2006-07-2007-09在门诊和住院患者共121例稳定性心绞痛(SAP)患者17例,急性冠脉综合征(ACS)患者82例],入院即刻抽取外周静脉血;将其中的41例 ACS 患者随机分为两组:在常规抗心绞痛治疗的基础上服用阿托伐他汀10 mg 组(20例)及阿托伐他汀40 mg 组(21例),治疗1月后抽取外周静脉血。观察指标为血脂、高敏 C 反应蛋白(hsCRP)、外周血 CD_(14)~+单核细胞表面 TLR4的表达,单核细胞表面 TLR4的表达采用流式细胞仪方法测定。结果 ACS 患者血 hsCRP 及外周血 CD_(14)~+单核细胞表面 TLR4的表达明显高于 SAP 患者(P<0.05)及正常对照组(P<0.05),hsCRP 与 TLR4的相关性分析结果是两者轻度相关(r=0.261,P=0.002)...
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| 关 键 词： | 急性冠脉综合征 阿托伐他汀 单核细胞 Toll 样受体4 |
Atorvastatin Decreases TLR4 Expression on Circulating CD_(14)~+ Monocytes in Patients with Acute Coronary Syndromes |
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| NIU Nan QU Peng XU Dan CUI Ying DING Yan-chun WANG Hong-yan ZHU Ning CHEN Hai-ying.Atorvastatin Decreases TLR4 Expression on Circulating CD_(14)~+ Monocytes in Patients with Acute Coronary Syndromes[J].Chinese Journal of Hypertension,2008(5). |
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| Authors: | NIU Nan QU Peng XU Dan CUI Ying DING Yan-chun WANG Hong-yan ZHU Ning CHEN Hai-ying |
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| Institution: | NIU Nan QU Peng XU Dan CUI Ying DING Yan-chun WANG Hong-yan ZHU Ning CHEN Hai-ying Department of Cardiology,Second Affiliated Hospital of Dalian Medical University,Dalian 116027,China |
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| Abstract: | Objective Previous studies indicated that activation of Toll-like receptor4 (TLR4) was involved in the progression and instability of atherosclerotic plaque.Anti-inflammatory effects were shown in statins. However,the mechanisms underlying these effects have not been well explored.We test the hypothesis that a por- tion of these anti-inflammatory effects are mediated by regulation of TLR4 expression.Methods One hundred twenty-one subjects (22 normal persons,17 patients with stable angina and 82 patients wit... |
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| Keywords: | Acute coronary syndrome Atorvastatin Monocytes Toll-like receptor4 |
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