Localization of a non-specific X-linked mental retardation gene, MRX23, to Xq23-q24 |
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| Authors: | Gregg, RG Palmer, C Kirkpatrick, S Simantel, A |
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| Affiliation: | Waisman Center for Mental Retardation and Human Development, University of Wisconsin, Madison 53706, USA. |
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| Abstract: | More than 100 X-linked mental retardation syndromes have been described. Wereport the localization of the disease gene, MRX23, in one family toXq23-24. Affected family members present with non- specific X-linked mentalretardation with verbal disability (BDOAS 10, 1-100). MRX23 is tightlylinked to the markers DXS1220 (Z = 3.76 at theta = 0.1) and DXS424 (Z = 3.9at theta = 0.06). Multipoint linkage analysis, taking five loci(DXS1072-0.07-DXS1220-0.014-MRX23-0.01-DXS 424-0.08-DXS1001) at a time,gives a maximum LOD score of 6.7 between these two markers. The next mostlikely location, between DXS424 and DXS1001 is 120-fold less likely.Haplotype analysis also indicates the most likely location for the diseasegene is between DXS1220 and DXS424. |
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