妊娠期生理特点与宫颈癌的关系及围妊娠期宫颈癌筛查的意义

目的 探讨妊娠期生理特点与宫颈癌的关系及加强宫颈疾病史妇女围妊娠期宫颈癌筛查的意义.方法 选取2018年1月至2020年1月间陕西省西安医学院第二附属医院妇产科门诊建立档案并接受正规产前检查的22141例孕妇作为研究对象,根据是否处于妊娠期进行分组,妊娠期3328例,非妊娠期18813例.按照自愿原则,受检者接受液基细...

Association between physiological characteristics during pregnancy and cervical cancer and the significance of cervical cancer screening

Objective To explore the relationship between the physiological characteristics during pregnancy and cervical cancer and the significance of strengthening cervical cancer screening in women with a history of cervical disease.Methods From January 2018 to January 2020,22141 pregnant women who established files and received regular antenatal examinations were selected as research subjects at Second Affiliated Hospital of Xi’an Medical College.They were categorized into a pregnancy group(3328 women)and a non-pregnancy group(18813 women).A total of 3328 women underwent thin prep liquid-based cytology(TCT)examination based on the intention-to-treat principle.For those with abnormal TCT results and cervical lesions,a TCT review was performed at 6 weeks after delivery.Non-pregnant women who received cervical cancer screening were selected the in the same period and the TCT test results were analyzed.Results The results of TCT examination showed that there was no significant difference in positivity rate between the groups(P>0.05).In terms of high grade squamous intraepithelial lesion(HSIL),the nonpregnant group was significantly higher than the pregnant group(P<0.05).There were no significant differences in atypical squamous cells of undetermined significance(ASC-US),low-grade squamous intra-epithelial lesion(LSIL),atypical squamous cells:cannot exclude high-grade squamous intraepithelial lesion(ASC-H),squamous cell carcinoma(SCC)and atypical glandular cells(AGC)between the two groups(P>0.05).Cervical biopsy results showed that there was no significant difference in cervical intraepithelial neoplasia(CIN)and the incidence,biopsy rate and positivity rate of cervical cancer between the two groups(P>0.05).A total of 134 pregnant women with abnormal cytology were followed-up.The rate of cytological negative conversion was 68.7%(92/134).Colposcopy examination found that inflammation/Human papillomavirus(HPV)infection occurred in 6 patients,CIN Ⅰ occurred in 5 patients,CIN Ⅱ occurred in 3 patients and CIN Ⅲ occurred in 2 patients.Conclusion Most pregnant women with cervical lesions will recover spontaneously or no progress after delivery with good prognosis.