外周血中性粒细胞/淋巴细胞比值对维持性腹膜透析患者心血管事件的预测价值

目的 探讨外周血中性粒细胞/淋巴细胞比值(NLR)对维持性腹膜透析(MPD)患者心血管事件发生的预测价值,为临床诊治提供理论依据.方法 选取2016年1月1日-2018年5月1日某院肾内科133例MPD患者作为研究对象,收集并记录临床基本资料和实验室检测结果.随访24个月,根据心血管事件的发生情况分为心血管事件组(52...

The Predictive Value of Peripheral Blood Neutrophil-to-lymphocyte Ratio for Cardiovascular Events in Maintenance Peritoneal Dialysis Patients

Objective To explore the predictive value of peripheral blood neutrophil-to-lymphocyte ratio(NLR) in the cardiovascular events in patients with maintenance peritoneum dialysis(MPD), and to provide theoretical basis for clinical diagnosis and treatment. Methods From January 1 st, 2016 to May 1 st, 2018, 133 patients with MPD which were selected as the study objects, and to collect the basic clinical data and laboratory test results. After 24 months follow-up, according to the occurrence of cardiovascular events, the patients were divided into the cardiovascular event group(52 cases) and the non-cardiovascular event group(81 cases). The working curve of subjects was used to analyze the predictive value of peripheral blood NLR on cardiovascular event death in maintenance peritoneal dialysis patients. Kaplan Meier method was used to draw the cumulative occurrence curve of cardiovascular events in maintenance peritoneal dialysis patients. The multivariate logistic regression was used to analyze the influencing factors of cardiovascular events in maintenance peritoneal dialysis patients. Results The level of NLR in the cardiovascular event group was significantly higher than that of in the non-cardiovascular event group(P<0.05). The ROC curve analysis showed that AUC was 0.753, sensitivity and specificity were 84.62% and 71.60% respectively. Kaplan Meier curve analysis showed that the cumulative incidence of cardiovascular events in patients with NLR≥2.84 was higher than that of in patients with NLR<2.84(log rank test: χ²=8.055, P=0.005). Multivariate logistic regression analysis showed that age(OR=1.352, 95%CI: 1.068~1.712, P=0.012), diabetes(OR=1.834, 95%CI:1.178~2.854, P=0.007) and high level NLR(OR=2.133, 95% CI:1.135~4.006, P=0.019) were the influence factors of cardiovascular events in MPD patients. Conclusions The level of peripheral blood NLR of MPD patients with cardiovascular events was significantly increased, and high level of NLR was the influencing factor of MDP patients with cardiovascular events, which could be used as a marker to predict the occurrence of cardiovascular events in MPD patients.