生脉注射液联合厄贝沙坦治疗冠心病慢性心力衰竭的疗效

目的研究生脉注射液联合厄贝沙坦治疗冠心病慢性心力衰竭的疗效。方法选取我院2017年3月—2018年3月收治的100例慢性心力衰竭患者,随机分为两组各50例。对照组患者口服厄贝沙坦片,1片/次,1次/d,治疗组患者在对照组基础上每日给予生脉注射液,将30 mL生脉注射液溶于250 mL 5%葡萄糖注射液中,两组患者均持续治疗30 d。对比两组临床疗效、心功能相关指标、IL-6、CRP和TNF-α水平、临床症状消失时间和不良反应发生率。结果治疗后治疗组治疗有效率较高(P<0.05);两组患者心输出量(cardiac output,CO)、心脏指数(cardiac index,CI)、有效循环血量(effective circulatory volume,ECV)和心肌耗氧量(myocardial oxygen consumption,MVO)水平均低于治疗前(P<0.05);并且治疗组降低程度较大(P<0.05);两组患者左室射血分数(left ventricular ejection fraction,LVEF)、左室舒张末期内径(left ventricular end-diastolic dimension,LVDd)、室间隔厚度(interventricular septal thickness,IVST)、左室后壁厚度(left ventricular posterior wall thickness,LVPWT)改善(P<0.05);并且治疗组改善程度较大(P<0.05);两组患者C反应蛋白(C-reactive protein,CRP)、肿瘤坏死因子α(tumor necrosis factor-α,TNF-α)和白介素-6(Interleukin-6,IL-6)水平低于治疗前(P<0.05);并且治疗组降低程度较大(P<0.05)。结论慢性心力衰竭采用生脉注射液联合厄贝沙坦进行治疗,具有较好的临床疗效。

The Effects of Shengmai Injection Combined With Irbesartan in Treatement of Coronary Heart Disease Chronic Heart Failure

Objective To study effects of Shengmai injection combinedwith irbesartan in treatement of coronary heart disease chronic heart failure.Methods The 100 cases of patients with chronic heart failure in our hospital from March 2017 to March 2018 were randomly divided into two groups,50 cases each.Sand control in patients with oral he piece,1 piece/times,1 time/d,the treatment group patients in the control group on the basis of the daily life Shengmai injection.The 30 mL Shengmai injection was dissolved in 250 mL of 5%glucose injection,two groups of patients were continue treatment for 30 d.The clinical curative effect,related parameters of cardiac function,IL-6,CRP and TNF-αlevel,clinical symptoms disappear time and incidence of adverse reactions were compared.Results After treatment,the effective rate of the treatment group was higher(P<0.05).Cardiac output(CO),Cardiac index(CI),effective circulatory volume(ECV)and myocardial oxygen consumption(MVO)in the two groups were significantly lower than before treatment(P<0.05).The degree of reduction in the treatment group was significant(P<0.05).Patients in the two groups had Left ventricular ejection fraction(LVEF),left ventricular end-Diastolic dimension(LVDd),interventricular septal thickness(IVST),and left ventricular posterior wall It was added to thickness with significant improvement in LVPWT(P<0.05).In addition,the treatment group showed significant improvement(P<0.05).The levels of C-reactive protein(CRP),tumor necrosis factor(TNF-),and interleukin-6(IL-6)in the two groups were significantly lower than those before treatment(P<0.05).In addition,the degree of reduction was greater in the treatment group(P<0.05).Conclusion The chronic heart failure was treated with Shengmai injection combined with irbesartan.It has good clinical curative effect.