肺癌合并冠心病患者行同期手术的预后影响因素分析

目的 探讨肺癌合并冠心病患者行同期外科手术的预后影响因素.方法 选取2017年1月至2019年12月间葫芦岛市中心医院收治的100例行同期外科手术治疗的肺癌合并冠心病患者,根据预后结局分为预后良好组79例和预后不良组21例,分析影响预后不良的危险因素,探讨癌胚抗原(CEA)与CD4+和CD8+的相关性,分析肌酸激酶MB...

Factors influencing prognosis in patients with lung cancer complicated with coronary heart disease undergoing concurrent surgery

Objective To analyze the risk factors that influence the prognosis of patients with lung cancer complicated with coronary heart disease undergoing concurrent surgery.Methods One hundred patients with lung cancer complicated with coronary heart disease were selected as the research subjects at Huludao Central Hospital from January 2017 to December 2019.They were divided into a good prognosis group(79 patients)and a poor prognosis group(21 patients)based on the prognosis.Risk factors that influence the prognosis were analyzed,and the correlation between carcinoembryonic antigen(CEA)and CD4⁺,and CD8⁺,and the relationship between creatine kinase isoenzyme-MB(CK-MB)and New York Heart Association(NYHA)classification and left ventricular ejection fractions(LVEF)were discussed.Results There was no significant difference in gender,clinical stage,pathological type,triglycerides(TG),total cholesterol(TC),high density lipoprotein cholesterol(HDL-C)and low density lipoprotein cholesterol(LDL-C)between the two groups(P>0.05).There were significant differences in age,NYHA classification,CEA,CK-MB,the first second of forced expiration(FEV1)/forced vital capacity(FVC),LVEF,CD4⁺,and CD8⁺between the two groups(all P<0.05).Multivariate logistic regression analysis showed that age≥60 years old,NYHA classⅢtoⅣ,positive CEA,CK-MB>24 U/L,FEV1/FVC<70%,LVEF<50%,CD4⁺,and CD8⁺were independent risk factors influencing prognosis(P<0.05).CEA was positively associated with CD4⁺,and negatively associated with CD8⁺(all P<0.05).CK-MB was positively correlated with NYHA grade and LVEF(all P<0.05).Conclusion Age,NYHA classification,CEA,CK-MB,lung function,LVEF and immune function are risk factors influencing the prognosis of patients with lung cancer complicated with coronary heart disease undergoing concurrent surgery.Clinically,targeted intervention programs should be formulated in accordance with the specific conditions of the patients and avoid the factors influencing the outcomes.