扶正化瘀消癌汤和多西紫杉醇对老年宫颈癌复发患者生活质量及预后的影响

目的探讨扶正化瘀消癌汤联合多西紫杉醇对老年宫颈癌复发患者生活质量及预后的影响。方法选取2018年6月至2019年12月间沈阳红十字会医院收治的128例老年宫颈癌复发患者,采用随机数字表法分为观察组62例和对照组66例,对照组患者采用多西紫杉醇化疗治疗,观察组患者在此基础上联合扶正化瘀消癌汤治疗,比较两组患者治疗前后的生活质量、治疗安全性和生存率。结果治疗后,两组患者各项功能量表评分均升高,且观察组患者均高于对照组,差异均有统计学意义(均P<0.05)。治疗期间,两组患者肝肾功能损害发生率比较,差异无统计学意义(P>0.05),且两组均未出现严重肝肾功能损害病例。观察组患者胃肠道反应和骨髓抑制发生率均低于对照组,但差异无统计学意义(P>0.05)。观察组患者不良反应发生率为33.9%,低于对照组的56.1%,两组比较,差异有统计学意义(P<0.05)。观察组患者1年生存率和2年生存率均高于对照组,两组比较,差异有统计学意义(P<0.05)。结论扶正化瘀消癌汤联合多西紫杉醇能有效提高老年宫颈癌复发患者的生活质量,延长生存时间,提高生存率,缓解化疗不良反应,值得临床推广。

Effects of Fuzheng Huayu Xiaoai decoction combined with docetaxel on quality of life and prognosis of elderly patients with recurrent cervical cancer

Objective To explore the effect of Fuzheng Huayu Xiaoai decoction combined with docetaxel on quality of life and prognosis of elderly patients with recurrent cervical cancer.Methods A total of 128 elderly patients with recurrent cervical cancer who were treated at Shenyang Red Cross Hospital from June 2018 to December 2019 were selected as the research subjects.Using random number table method,the patients were divided into an observation group(62 patients)and a control group(66 patients).Patients in the observation group were treated with Fuzheng Huayu Xiaoai decoction based on chemotherapy with docetaxel and the control group were given chemotherapy with docetaxel.Quality of life,treatment safety and survival rate were compared between the two groups before and after the treatment.Results After the treatment,scores of function measures increased in both groups with the observation group higher than the control group(all P<0.05).There was no significant difference in the incidence of liver and kidney damage during the treatment period between the two groups(P>0.05).No severe liver and kidney damage occurred in either group.The incidence of gastrointestinal reactions and bone marrow suppression were significantly lower in the observation group than in the control group,and the incidence of adverse reactions was 33.9%in the observation group during treatment which was significantly lower than 56.1%of the control group(P<0.05).The 1-year and 2-year survival rate were significantly higher in the observation group than in the control group(all P<0.05).Conclusion Fuzheng Huayu Xiaoai decoction combined with docetaxel can effectively improve quality of life,prolong survival time and alleviate the adverse reactions caused by chemotherapy in elderly patients with recurrent cervical cancer and it is worthy of clinical promotion.