化学发光免疫法在原发性肝癌患者肿瘤标志物检验中的应用

目的 探讨原发性肝癌化学发光免疫法(CLIA)在肿瘤生物标志物检验中的应用价值.方法 选取2019年1月至2020年1月间西安国际医学中心医院收治的100例原发性肝癌患者纳入原发性肝癌组,另选取同期100例健康体检人员作为健康对照组.采用CLIA对血清甲胎蛋白(AFP)、α-L-岩藻糖苷酶(AFU)、γ-谷氨酰转肽酶(...

Chemiluminescence immunoassay for the detection of tumor biomarkers in primary liver cancer

Objective To study the application value of chemiluminescence immunoassay(CLIA)for the detection of tumor biomarkers in primary liver cancer.Methods One hundred patients with primary liver cancer treated at Xi'an International Medical Center Hospital from January 2019 to January 2020 were selected as primary liver cancer group,and 100 healthy persons were selected in the same period as healthy control group.The levels of tumor biomarkers such as serum alpha fetoprotein(AFP),α-L-Fucosidase(AFU),gamma glutamyl transpeptidase(GGT),carbohydrate antigen-199(CA-199)and carcinoembryonic glycogen(CEA)were detected by CLIA.The levels of tumor biomarkers were compared between the two groups.Results The serum levels of AFP,AFU,GGT,CA-199 and CEA were significantly higher in the primary liver cancer group than in the healthy control group(all P<0.05).The positivity rate of AFU,GGT,CA-199,CEA and AFP of the primary liver cancer group were gradually decreased,which were significantly lower than combination detection of the above indices and higher than the healthy control group(all P<0.05).Conclusion CLIA is of high value for the detection of tumor biomarkers in primary liver cancer,and the positivity rate of combination detection is higher than single detection.