| 五苓散的毒性评价 |
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| 引用本文： | 张银卿,王宁生,刘启德,叶少梅,欧卫平. 五苓散的毒性评价[J]. 中国现代药物应用, 2008, 2(12): 16-18 |
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| 作者姓名： | 张银卿 王宁生 刘启德 叶少梅 欧卫平 |
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| 作者单位： | 广州中医药大学临床药理所,510405 |
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| 摘 要： | 目的对五苓散（WLS）的长毒作用进行评价。方法观察给药后大鼠的一般症状、血液学、血液生化学、系统尸检和恢复期的有关指标,对WLS进行安全毒理学评价。结果对血液学及血液生化指标有一定的影响,主要表现在白细胞数分类及血红蛋白的改变（有统计学意义）,但停药后基本恢复。三个剂量组大鼠的心、脾、肺、肾上腺、前列腺、卵巢、子宫或睾丸（连附睾）、脑等脏器系数均无明显改变。结论临床应用需注意肝、肾脏和睾丸等脏器的毒性表现。
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| 关 键 词： | 五苓散 长毒药效实验 毒性 脏器 |
Evaluation of Toxicity of WLS |
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| Affiliation: | ZHANG Yin-qing, WANG Ning-sheng, Liu Qi-de et al. (Institute of Clinical Pharmacology, Guangzhou University of Chinese Medicine, Guangzhou 510405, China) |
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| Abstract: | Objective The aim of this work was to evaluate the long-term toxic effects of WLS. Methods Targets were observed after oral administration of WLS. Results Some targets were influenced after oral administration of WLS （P 〈 0. 05 ）, Conclusion The toxic effects of some organ such as liver, kidney and testicle should be paid attention when it used in clinical therapy. |
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| Keywords: | WLS Long-term toxicity |
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