K+ channel activator inhibition of neurogenic goblet cell secretion in guinea pig trachea. |
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| Authors: | H P Kuo J A Rohde P J Barnes D F Rogers |
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| Affiliation: | Department of Thoracic Medicine, National Heart and Lung Institute, London, UK. |
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| Abstract: | A potassium (K+) channel activator, BRL 38227, inhibited goblet cell secretion in guinea-pig trachea induced by either electrical stimulation of the vagus nerves or acute inhalation of cigarette smoke, two stimuli which activate both cholinergic nerves and capsaicin-sensitive sensory nerves. BRL 38227 failed to inhibit methacholine- or substance P-induced goblet cell secretion which suggests that K+ channel activators inhibit neurogenic goblet cell secretion via a prejunctional effect on cholinergic and sensory nerves. |
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