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| 注射用头孢尼西钠在3种输液中的配伍稳定性研究 | |
| 引用本文： | 萧绮珊,林艳云,崔丹燕. 注射用头孢尼西钠在3种输液中的配伍稳定性研究[J]. 中国医药导报, 2010, 7(22): 87-89 |
| 作者姓名： | 萧绮珊 林艳云 崔丹燕 |
| 作者单位： | 1. 广东省中山市药品检验所,广东,中山,528437 2. 南方医科大学附属中山市博爱医院,广东,中山,528400 3. 广东药学院中山校区,广东,中山,528400 |
| 摘 要： | 目的：考察注射用头孢尼西钠与葡萄糖氯化钠注射液、5%葡萄糖注射液和0.9%氯化钠注射液的配伍稳定性。方法：考察配伍后溶液的外观性状,采用HPLC法对配伍后溶液的含量变化进行分析。结果：注射用头孢尼西钠与葡萄糖氯化钠注射液、5%葡萄糖注射液和0.9%氯化钠注射液在6h内配伍稳定,在外观性状和含量上无显著变化;与0.9%氯化钠注射液配伍的稳定性优于其他两种注射液。结论：注射用头孢尼西钠与葡萄糖氯化钠注射液、5%葡萄糖注射液和0.9%氯化钠注射液配伍稳定,为临床使用提供有效的依据。 |
| 关 键 词： | 注射用头孢尼西钠 高效液相色谱法 稳定性 |
Stability of Cefonicid Sodium for Injection in the three kinds of infusion |
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| XIAO Qishan,LIN Yanyun,CUI Danyan. Stability of Cefonicid Sodium for Injection in the three kinds of infusion[J]. China Medical Herald, 2010, 7(22): 87-89 | |
| Authors: | XIAO Qishan LIN Yanyun CUI Danyan |
| Affiliation: | 1.Institute for Drug Control of Zhongshan City,Zhongshan 528437,China;2.Zhongshan Bo＇ai Affiliated Hospital of Southern Medical University,Zhongshan 528400,China;3.Zhongshan Campus,Guangdong Pharmaceutical University,Zhongshan 528400,China) |
| Abstract: | Objective：To survey the compatible stability of Cefonicid Sodium for Injection in the three kinds of infusion-Glucose and Sodium Chloride Injection,5% Glucose Injection and 0.9% Sodium Chloride Injection.Methods：Cefonicid Sodium for Injection was observed the the outward appearance and measured the content of cefonicid in the compatible solution by HPLC.Results：The compatible stability of Cefonicid Sodium for Injection in the Glucose and Sodium Chloride Injection,5% Glucose Injection and 0.9% Sodium Chloride Injection was stable in 6 h,and there were no obvious changes in outward appearance and content.Conclusion：A determination of the stability of Cefonicid Sodium for Injection can provide a effective basis for clinical application. |
| Keywords: | Cefonicid Sodium for Injection HPLC Stability |
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