灵芝促学习记忆及抗衰老作用实验研究

目的 :研究灵芝对血虚小鼠自发行为、学习记忆及抗衰老作用。方法 :血虚小鼠用灵芝水煎剂 ,对照组小鼠用生理盐水灌胃 ,连续 13d,期间进行小鼠开场行为和学习记忆的测定 ,以及小鼠应急力竭游泳后 2 4 h分别对小鼠脑、肝的超氧化物歧化酶 (SOD)的活性 ,脑、肝、心、脾、肌的丙二醛 (MDA)、脂褐素 (L PF)含量进行测定。结果 :灵芝对血虚小鼠开场行为中的理毛次数有显著影响 (P<0 .0 5 ) ,但对移动隔数、站立次数以及学习记忆未产生显著影响。灵芝能显著提高血虚小鼠脑、肝中的 SOD活性 (P<0 .0 5 ) ,显著降低脑、肝、心、脾、肌的 MDA、L PF的含量 (P<0 .0 5 )。结论 :灵芝可促进血虚小鼠的自发活动 ,且抗衰老作用显著

Effects of Ganderma lucidum on the Learning and Memory Abilities and Resisting Senility

Objective: To study the effects of Ganderma lucidum on the learning and memory abilities and resisting senility. Methods: The anemia mice were fed with Ganderma lucidum 10 g/kg body weight while control group were fed with physiological saline for 13 days. During the time, the open field behavior and learning and memory abilities were observed. Then the mice have been swimming about 2 hours, 24 hours after the emergent swimming, the activities of SOD in brain and liver, the contents of MDA and LPF in brain, liver, heart, spleen, and muscle were detected. Results: Ganderma lucidum has obvious effect on grooming times of Anemia mice (P<0.05),but there is no obvious effects on locomotion,rearing and learning and memory ability. Ganderma lucidum can improve the activity of SOD (P<0.05)and bring down the level of MDA and LPF (P<0.05)significantly. Conclusion: Ganderma Lucidum has function of improve the spontaneous activities and resist senility of Anemia mice.