Local and distant recurrences in rectal cancer patients are predicted by the nonspecific immune response; specific immune response has only a systemic effect - a histopathological and immunohistochemical study期刊界 All Journals 搜尽天下杂志传播学术成果专业期刊搜索期刊信息化学术搜索

Local and distant recurrences in rectal cancer patients are predicted by the nonspecific immune response; specific immune response has only a systemic effect - a histopathological and immunohistochemical study

Authors:	Iris D Nagtegaal Corrie AM Marijnen Elma Klein Kranenbarg Adri Mulder-Stapel Jo Hermans Cornelis JH van de Velde J Han JM van Krieken

Affiliation:	(1) Department of Pathology, Leiden University Medical Center, Leiden, The Netherlands;(2) Surgery, Leiden University Medical Center, Leiden, The Netherlands;(3) Clinical Oncology, Leiden University Medical Center, Leiden, The Netherlands;(4) Medical Statistics, Leiden University Medical Center, Leiden, The Netherlands;(5) Pathology, University Medical Centre St. Radboud, Nijmegen, The Netherlands

Abstract:	Background Invasion and metastasis is a complex process governed by the interaction of genetically altered tumor cells and the immunological and inflammatory host reponse. Specific T-cells directed against tumor cells and the nonspecific inflammatory reaction due to tissue damage, cooperate against invasive tumor cells in order to prevent recurrences. Data concerning involvement of individual cell types are readily available but little is known about the coordinate interactions between both forms of immune response.

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