哮喘动物模型的研究现状

通过对近年来国外哮喘实验研究文献进行总结，从制备哮喘模型常用动物的选择、制备模型的要素到哮喘模型的研究应用等方面进行综合分析，指出各种常用哮喘实验动物在哮喘研究中的适用范围，目前豚鼠仍是常用的哮喘实验动物，但是大小鼠的应用也日渐增多。在文献数据等结论基础上评价各种制备方法之特点，对改进方法进行详细描述及评价。最后对动物模型在哮喘发病机制中的应用，尤其是免疫发病机制中细胞因子与哮喘动物模型的关系进行了较为详细的阐述分析。指出应根据不同的哮喘临床类型及研究目的选用相应的方法对实验动物进行致敏及激发。

The Current Situation of Researches on Animal Model of Asthma

Through reviewing recent experimental resear ch literature of asthma in foreign countries,a comprehensive analysis is carried out from selecting experimental animals in commom use for asthma researches to essential factors of preperation of an animal model in research work.At present d ay,the guinea pig is still the wildly used experimental animal for asthma experi ment,while the use of rats and mice is increasing day by day.On the basis of the data of literature,the property of all kinds of methods is assessed and the imp roved method is described.The detailed exposition is given to the application of animal model of asthma in the researches of mechanisms of asthma onset,especial ly the cytokines of immmne system which are related with the mechanisms.It is em phasized that experimental animals should be sensitized and chanllenged accordin g to different clinical types and purposes of the researcher.