| 慢性发绀型肺血减少先天性心脏病幼猪模型的建立与病理学观察 |
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| 引用本文： | 王栋,刘迎龙,吕小东,朱耀斌,凌锋,刘爱军,李刚,续玉林.慢性发绀型肺血减少先天性心脏病幼猪模型的建立与病理学观察[J].心肺血管病杂志,2011,30(4):332-336. |
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| 作者姓名： | 王栋 刘迎龙 吕小东 朱耀斌 凌锋 刘爱军 李刚 续玉林 |
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| 作者单位： | 北京协和医学院,中国医学科学院阜外心血管病医院小儿心脏中心,北京,100037 |
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| 基金项目： | 北京自然科学基金课题(7072049) 国家自然科学基金资助项目 |
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| 摘 要： | 目的:采用人工血管肺动脉(PA)-左心房(LA)分流与肺动脉环缩的方法建立慢性发绀型肺血减少先天性心脏病(先心病)幼猪模型。方法:将6～8 w龄幼猪分2组,肺血减少组7只,行人工血管PA-LA分流及PA远端环缩;对照组6只,仅开胸。饲养4 w后行二次手术,评估建模效果。结果:对照组均存活,肺血减少组存活6只。肺血减少组跨肺动脉环缩处收缩压差由(10.33±6.09)mmHg(1 mmHg=0.133 kPa)增至4 w后的(19.67±4.76)mmHg,P=0.011。与对照组比较,肺血减少组动脉血氧饱和度(SaO2)、动脉氧分压(PaO2)、动脉血二氧化碳分压(PaCO2)、血红蛋白含量(Hb)和血细胞比容(Hct)差异均有统计学意义(P<0.05)。2组幼猪肺脏、心脏组织比较有明显的病理学特征差异。结论:应用人工血管PA-LA分流与PA环缩的方法成功建立慢性发绀型肺血减少先心病动物模型,创伤小、可重复性高。
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| 关 键 词： | 发绀 先天性心脏病 动物模型 幼猪 病理 |
Development and pathological observation on a chronic cyanotic porcine model with decreased pulmonary blood flow |
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| WANG Dong,LIU Yinglong,LV Xiaodong,ZHU Yaobin,LING Feng,LIU Aijun,LI Gang,XU Yulin.Development and pathological observation on a chronic cyanotic porcine model with decreased pulmonary blood flow[J].Journal of Cardiovascular and Pulmonary Diseases,2011,30(4):332-336. |
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| Authors: | WANG Dong LIU Yinglong LV Xiaodong ZHU Yaobin LING Feng LIU Aijun LI Gang XU Yulin |
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| Institution: | WANG Dong,LIU Yinglong,LV Xiaodong,ZHU Yaobin,LING Feng,LIU Aijun,LI Gang,XU Yulin Department of Pediatric Cardiac Surgery,Cardiovascular Institute and Fuwai Hospital,Chinese Academy of Medical Sciences & Peking Union Medical College,Beijing 100037,China |
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| Abstract: | Objective:To create an experimental model of chronic cyanotic piglet model with decreased pulmonary blood flow using pulmonary artery(PA)-left atrial(LA) shunt with pulmonary artery banding,and optimize experimental protocol in order to improve repeatability of this model.Methods:In 7 piglets(6-8 weeks old),a beveled,5 mm,polytetrafluoroethylene(Gore-Tex) tube graft was anastomosed to the PA and LA,and then surgical pulmonary artery banding was operated(cyanotic model group).Another 6 piglets underwent sham... |
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| Keywords: | Cyanosis Congenital heart disease Animal model Piglet Pathology |
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