| 血清中性粒细胞明胶酶相关载脂蛋白对过敏性紫癜早期肾损害诊断的价值 |
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| 引用本文： | 张玉晶,孙昱,赵霞霞. 血清中性粒细胞明胶酶相关载脂蛋白对过敏性紫癜早期肾损害诊断的价值[J]. 中国实验诊断学, 2011, 15(8): 1320-1321 |
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| 作者姓名： | 张玉晶 孙昱 赵霞霞 |
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| 作者单位： | 1. 哈尔滨医科大学附属第二医院,黑龙江,哈尔滨150086
2. 吉林大学第三临床医院,吉林,长春130033 |
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| 摘 要： | 目的研究血清中性粒细胞凝胶酶载脂蛋白（NGAL）对过敏性紫癜患儿早期肾损伤诊断的价值。方法对42例过敏性紫癜患儿其中男26例、女16例,根据24h尿蛋白定量或尿红细胞分为三组：H1组（18例）：尿蛋白、尿红细胞正常;轻度肾损害组H2组（14例）：尿微量白蛋白〈40 mg/m2/h或镜下血尿;H3组（10例）：大量蛋白尿〉40 mg/m2/h;另取同期门诊健康体检患儿12例做C组对照组。每组均采用ELISA法检测患者血清NGAL（sNGAL）水平,全自动生化仪检测血肌酐及尿素氮。结果过敏性紫癜患儿血清NGAL水平随着尿蛋白排除增加而升高,各组之间比较差异均有统计学意义（P〈0.05）;血清NGAL在肌酐和尿素氮正常时就可明显升高;尿蛋白正常组和尿蛋白异常组的血清NGA水平差异有统计学意义（P〈0.05）。结论血清NGAL的测定对过敏性紫癜早期肾损伤的诊断具有良好的临床价值。
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| 关 键 词： | 中性粒细胞明胶酶载脂蛋白 过敏性紫癜 肾损害 |
Diagnose value of NGAL on early-stage renal injury of Henoch-schonlein purpura patient |
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| ZHANG Yu-jing,SUN Yu,ZHAO Xia-xia. Diagnose value of NGAL on early-stage renal injury of Henoch-schonlein purpura patient[J]. Chinese Journal of Laboratory Diagnosis, 2011, 15(8): 1320-1321 |
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| Authors: | ZHANG Yu-jing SUN Yu ZHAO Xia-xia |
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| Affiliation: | ZHANG Yu-jing1,SUN Yu2,ZHAO Xia-xia1.(The 2th Hospital of Haerbin Medical Science University,Heilongjiang Haerbin 150086,China) |
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| Abstract: | Objective To study the value of NGAL on renal injury diagnose of patient who has henoch-schonlein purpura in the early stage.Methods 42 henoch-schonlein purpura patients were selected inclduing 26 male and 16 female.According to 24 hours urinary protein count or Urine red blood cell,42 patients were grouped into three:group H1(18cases):both urinary protein and Urine red blood cell are normal;group H2(14cases):micro-urinary protein is lower than 40 mg/m2/h or microscopic hematuria;group H3(10cases):amount ur... |
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| Keywords: | NGAL henoch-schonlein purpura Renal injury |
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