进展期结直肠癌术前经直肠5-Fu化疗的疗效观察

目的　探讨术前经直肠 5 -Fu化疗对进展期结直肠癌术后生存率的影响。方法　统计进展期结直肠癌术前经直肠 5 -Fu化疗病例 112例及对照组 14 4例 ,观察化疗反应情况并比较两组术后并发症、局部复发率、5年生存率。结果　两组术后并发症、局部复发率无显著性差异 (P >0 .0 5 ) ,但化疗组中B期病人及直肠癌病人 5年生存率均显著高于对照组 (P <0 .0 5 )。结论　进展期结直肠癌术前经直肠 5 -Fu化疗是一种有效、安全、方便的治疗措施 ,具有一定的提高生存率的作用 ,可作为术前常规应用。

Clinical efficacy of preoperative 5-Fu infusion via rectum cavity before surgery for advanced colon-rectum carcinoma patients

Objective The influence of preoperative 5-Fu infusion via rectum cavity to the survival rate for patients with advanced colon-rectum carcinoma was discussed. Methods One hundred and twelve cases of colon-rectum carcinoma received 5-Fu infusion via rectum cavity before surgery (Group A), 144 ones received surgery only (Group B) without the above chemotherapy. Chemotherapy response was observed, further, the difference of surgical complications. Local recurrence rate and 5-year survival rate between 2 groups was analyzed. Results There was no significant difference (P>0.05) in surgical complication occurrences and local recurrence rate between two groups. The 5-year survival rate of those patients with Duke's B and rectum carcinoma in group A was significantly higher than that of patients in group B (P<0.05). Conclusion Chemotherapy with 5-Fu infusion via rectum cavity before surgery is an effective, safe and convenient therapy method against advanced colon-rectum carcinoma,can enhance long-term survival rate definitely.