The effect of neuropeptide Y on striatal catecholamines |
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| Authors: | M F Beal R C Frank D W Ellison J B Martin |
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| Affiliation: | 1. Epidemiology Branch, National Institute of Environmental Health Sciences, Research Triangle Park, NC, USA;2. Department of Neurology, Pennsylvania State University-Milton S. Hershey Medical Center, Hershey, PA, USA;3. Molecular Genetics Section, Laboratory of Neurogenetics, National Institute on Aging, Bethesda, MD, USA;1. Department of Biological Sciences, Cork Institute of Technology, Cork, Ireland;2. Department of Anatomy and Neuroscience & Cork Neuroscience Centre, University College Cork, Cork, Ireland;3. Department of Physiology, University College Cork, Cork, Ireland;1. Department of Spine Surgery, Chifeng Municipal Hospital, Chifeng City, Inner Mongolia Autonomous Region, 024000, China;2. Department of Trauma Orthopedics, Chifeng Municipal Hospital, Chifeng City, Inner Mongolia Autonomous Region, 024000, China;1. Departmento de Toxicología, Centro de Investigación y de Estudios Avanzados del IPN, Mexico City, 07360, Mexico;2. Departmento de Fisiología, Biofísica y Neurociencias, Centro de Investigación y de Estudios Avanzados del IPN, Mexico City, 07360, Mexico;3. Facultad de Ciencias Químico Biológicas, Universidad Autónoma de Campeche, Campeche 4039, Mexico;4. Facultad de Ciencias de la Salud, Universidad Anáhuac Norte, 52786, Huixquilucan, Mexico |
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| Abstract: | Neuropeptide Y and peptide YY were injected into rat striatum and their effects on dopamine, serotonin and their metabolites were examined at 1 h. Neuropeptide Y induced a dose-dependent increase in dopamine turnover in the ipsilateral striatum with no effect on serotonin turnover. When neuropeptide Y was coinjected with somatostatin there was an additive effect in increasing dopamine turnover. There was no alteration in striatal concentrations of gamma-aminobutyric acid, glutamate, or aspartate with either neuropeptide Y or somatostatin injections. These results suggest that neuropeptide Y may play a role with somatostatin in regulating striatal dopaminergic transmission. |
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