tPSA、f/tPSA在不同数值范围时tPSA、fPSA、f/tPSA与前列腺癌相关性研究

目的研究tPSA、f/tPSA在不同数值范围时tPSA、fPSA、f/tPSA与前列腺癌的相关性。方法选择男性患者385人予血清tPSA、fPSA、f/tPSA测定,并行TRUS引导前列腺活检术或TURP术获得病理结果,对不同tPSA、f/tPSA范围内tPSA、fPSA、f/tPSA与前列腺癌作相关性分析。结果当tPSA≤4ng/ml时,tPSA、fPSA、f/tPSA均与PCa无显著相关性(P>0.05);当40.05);当tPSA≥20ng/ml时,tPSA与PCa有显著相关性(P<0.05),而fPSA、f/tPSA则与PCa无显著相关性(P>0.05)。当f/tPSA<0.1时,tPSA与PCa有显著相关性(P<0.05),而fPSA、f/tPSA则与PCa无显著相关性(P>0.05);当f/tPSA≥0.1时,tPSA、fPSA均与PCa有显著相关性(P<0.05),而f/tPSA与PCa无显著相关性(P>0.05)。结论tPSA、f/tPSA在不同数值范围时tPSA、fPSA、f/tPSA与PCa的相关性是存在差异的,应根据不同tPSA、f/tPSA的范围选择相关性显著的指标进行分析。

Research on the Correlation between tPSA,fPSA,f/tPSA and Prostate Cancer in Different Range of tPSA,f/tPSA

Objective To study the correlation between tPSA,fPSA,f/tPSA and prostate cancer in different range of tPSA,f/tPSA.Methods Levels of serums tPSA,fPSA,f/tPSA were measured in a total of 385 male patients.TRUS guided systematic prostate biopsy or TURP were performed and biopsy results were acquired to analyse the correlation between tPSA,fPSA,f/tPSA and prostate cancer in different range of tPSA,f/tPSA.Results TPSA,fPSA and f/tPSA had no correlation noticeably with PCa when tPSA was less than 4 ng/ml(P >0.05).When tPSA was within 4～20 ng/ml,f/tPSA had correlation noticeably with PCa(P <0.05),but not for tPSA and fPSA(P >0.05).When tPSA was more than 20 ng/ml,tPSA had correlation noticeably with PCa(P <0.05),but not for fPSA and f/tPSA(P >0.05).When f/tPSA was less than 0.1,tPSA had correlation noticeably with PCa(P <0.05),but not for fPSA and f/tPSA(P >0.05).When f/tPSA was more than 0.1,tPSA and fPSA all had correlation noticeably with PCa(P <0.05),but not for f/tPSA(P >0.05).Conclusions It has different correlation between tPSA,fPSA,f/tPSA and prostate cancer in different range of tPSA,f/tPSA.We should choose notable indes to analyse in different range of tPSA、 f/tPSA.