冠心宁注射液对糖尿病合并ST段抬高型急性心肌梗死经皮冠状动脉介入术后左室重构的影响

目的探讨冠心宁注射液对糖尿病合并ST段抬高型急性心肌梗死（STEAMI）急诊经皮冠状动脉介入术（PCI）后左室重构的影响。方法选择98例首发糖尿病合并STEAMI并接受急诊PCI治疗成功的患者，将患者随机分为两组：观察组（48例）和对照组（50例）。两组患者PCI术后均给予常规药物治疗，观察组另给予冠心宁注射液（20ml静脉滴注，1次，d，连用10d）治疗。比较两组患者术前及术后1周、1个月、6个月的左心室舒张末期容积指数（LVEDVI）、左心室收缩末期容积指数（LVESVI）和左心室射血分数（LVEF）。结果术后6个月观察组患者LVEDVI、LVESVI及LVEF分别为（64．5±6．3）ml／m^2、（30．8±3．7）ml／m^2和（0．53±0．05），对照组分别为（66．5±5．8）ml／m^2、（33．5±5．8）ml／m^2和（0．50±0．02），两组间差异均有统计学意义（P〈0．05）。结论冠心宁注射液可改善糖尿病合并STEAMI患者PCI术后的左室重构，使左室容积缩小，LVEF升高。

Effect of Perhexiline Injection on Left Ventricular Remodeling in Patients with Acute ST-elevation Myocardial Infarction Accompanied with Diabetes Mellitus Undergoing Percutaneous Coronary Intervention

Objective To evaluate the effect of perhexiline injection on left ventricular remodeling in patients with acute ST-elevation myocardial infarction (STEAMI) accompanied with diabetes mellitus undergoing emergent percutaneous coronary interventions (PCI). Methods Totally 98 patients with STEAMI accompanied with diabetes mellitus who underwent emergent PCI were randomly divided as trial group (n=48) and control group (n=50). All the patients in both groups were received the routine therapy after PCI. In addition, the patients in the trial group were received perhexiline injection therapy (20 ml intravenous transfusion, once a day, for successive ten days). The parameters of left ventricular end diastolic volume index (LVEDVI), left ventricular end-systolic volume index(LVESVI), and left ventricular ejection fraction (LVEF) were measured in both groups by echocardiography before the PCI, 1 week, 1 months and 6 months after PCI. Results Six months after PCI, the values of LVEDVI, LVESVI and LVEF were respectively (64.5±6.3)ml/m~2, (30.8±3.7)ml/m~2 and (0.53±0.05) of the patients in the trial group, which were respectively significantly different from(66.5±5.8)ml/m~2, (33.5±5.8) ml/m~2 and (0.50±0.02) of the control group (P<0.05). Conclusion The application of perhexiline injection in patients with STEAMI accompanied with diabetes mellitus undergoing primary PCI can attenuate left ventricular remodeling, making LVEDVI reduced and LVEF increased.