Preparation of [11C]methyl nona‐fluorobutyl‐1‐sulfonate ([11C]MeONf) and its use in the synthesis of [11C]‐6‐OH‐BTA‐1 |
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| Authors: | Dean Jolly Younes Lakhrissi Miriam M Kovacevic Howard Chertkow Ralf Schirrmacher |
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| Institution: | 1. McConnell Brain Imaging Centre, Montreal Neurological Institute, McGill University, 3801 University Street, Montreal Que., Canada H3A2B4;2. Department of Clinical Neuroscience, Sir Mortimer B. Davis, Jewish General Hospital, 3755 Chemin de la Cote St. Catherine, Montreal Que., Canada H3T1E2;3. Lady Davis Institute, Jewish General Hospital, Neurology and Neurosurgery, McGill University, 3755 Chemin de la Cote St. Catherine, Montreal Que., Canada H3T1E2 |
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| Abstract: | The rapid, simple and high‐yield synthesis of the extraordinarily reactive 11C‐methylating agent, 11C]methyl nona‐fluorobutyl‐1‐sulfonate (11C]MeONf), and its use in the synthesis of the promising β‐amyloid imaging agent, 11C]‐6‐OH‐BTA‐1, is reported. In terms of radioactive methylation yields, 11C]MeONf seems to surpass 11C]methyl trifluoromethansulfonate (11C]MeOTf) as a methylating agent in this particular case giving the 11C‐labelled compound in high‐preparative radiochemical yields between 27 and 29% EOS with a minimum formation of radioactive by‐products. Copyright © 2007 John Wiley & Sons, Ltd. |
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| Keywords: | 11C‐methylation nonaflate Pittsburgh compound |
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