Synthesis of (E)‐2,3′,4,5′‐tetramethoxy[2‐11C]stilbene |
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Authors: | Lutz Schweiger Stuart Craib Andrew Welch Tim A. D. Smith |
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Affiliation: | John Mallard Scottish PET Centre, School of Medical Sciences, University of Aberdeen, Foresterhill, Aberdeen AB25 2ZD, UK |
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Abstract: | In this paper, we describe the radiosynthesis of the compound (E)‐2,3′,4,5′‐tetramethoxy[2‐11C]stilbene, a potential, universal tumour positron emission tomography imaging agent. The production of (E)‐2,3′,4,5′‐tetramethoxy[2‐11C]stilbene was carried out via 11C‐methylation of (E)‐2‐(hydroxy)‐3′,4,5′‐trimethoxystilbene by using [11C]methyl trifluoromethanesulfonate ([11C]methyl triflate). (E)‐2,3′,4,5′‐tetramethoxy[2‐11C]stilbene was obtained with a radiochemical purity greater than 95% in a 20 ± 2% decay‐corrected radiochemical yield, based upon [11C]carbon dioxide. Synthesis, purification and formulation were completed on an average of 30 min following the end of bombardment (EOB). The specific radioactivity obtained was 1.9 ± 0.6 GBq/µmol at EOB. Copyright © 2007 John Wiley & Sons, Ltd. |
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Keywords: | 2,3′ ,4,5′ ‐tetramethoxy[2‐11C]stilbene CYP1B1 PET |
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