Synthesis of (E)‐2,3′,4,5′‐tetramethoxy[2‐11C]stilbene |
| |
Authors: | Lutz Schweiger Stuart Craib Andrew Welch Tim A D Smith |
| |
Institution: | John Mallard Scottish PET Centre, School of Medical Sciences, University of Aberdeen, Foresterhill, Aberdeen AB25 2ZD, UK |
| |
Abstract: | In this paper, we describe the radiosynthesis of the compound (E)‐2,3′,4,5′‐tetramethoxy2‐11C]stilbene, a potential, universal tumour positron emission tomography imaging agent. The production of (E)‐2,3′,4,5′‐tetramethoxy2‐11C]stilbene was carried out via 11C‐methylation of (E)‐2‐(hydroxy)‐3′,4,5′‐trimethoxystilbene by using 11C]methyl trifluoromethanesulfonate (11C]methyl triflate). (E)‐2,3′,4,5′‐tetramethoxy2‐11C]stilbene was obtained with a radiochemical purity greater than 95% in a 20 ± 2% decay‐corrected radiochemical yield, based upon 11C]carbon dioxide. Synthesis, purification and formulation were completed on an average of 30 min following the end of bombardment (EOB). The specific radioactivity obtained was 1.9 ± 0.6 GBq/µmol at EOB. Copyright © 2007 John Wiley & Sons, Ltd. |
| |
Keywords: | 2 3′ 4 5′ ‐tetramethoxy[2‐11C]stilbene CYP1B1 PET |
|
|