| 肿瘤血管活性肠肽受体显像 |
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| 引用本文： | 王雪鹃,张梅颖,林保和. 肿瘤血管活性肠肽受体显像[J]. 国际放射医学核医学杂志, 2001, 25(2): 65-69 |
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| 作者姓名： | 王雪鹃 张梅颖 林保和 |
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| 作者单位： | 100036 北京, 北京大学临床肿瘤医院核医学科 |
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| 摘 要： | 血管活性肠肽(VIP)是一种由28个氨基酸组成具有多种功能的神经递质,能通过其受体调节正常及肿瘤细胞的增殖和分化。VPAC(VIP受体)广泛存在于各种正常和肿瘤组织中,但其在肿瘤组织中的表达密度远大于正常组织,这为放射性核素标记的血管活性肠肽受体显像奠定基础。此种显像已应用于多种肿瘤的诊断、分期、治疗方案选择与预后评价。
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| 关 键 词： | 肿瘤 血管活性肠肽 受体显像 |
| 文章编号： | 1001-098X(2001)02-0065-05 |
| 收稿时间： | 2000-05-11 |
| 修稿时间： | 2000-05-11 |
Tumor imaging of vasoactive intestinal peptide receptor |
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| WANG Xue-juan,ZHANG Mei-ying,LIN Bao-he. Tumor imaging of vasoactive intestinal peptide receptor[J]. International Journal of Radiation Medicine and Nuclear Medicine, 2001, 25(2): 65-69 |
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| Authors: | WANG Xue-juan ZHANG Mei-ying LIN Bao-he |
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| Affiliation: | Department of Nuclear Medicine, Affiliated Tumor Hospital, Peking University, Beijing 100036, China |
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| Abstract: | Vasoactive intestinal peptide (VIP) is a naturally occurring 28 amino acid peptide with a wide range of biological activities. It can regular the cellular proliferaton and differentiation through its receptors. Recent reports suggest that VIP receptors are expressed on a variety of malignant tumor cells and that the receptor density is higher than normal tissue. The high expression of VIP receptors provided the basis for the clinical use of radiolabeled VIP for the in vivo localization of the malignant tumors. The imaging has been used for diagnosis, staging, therapy strategy and prognosis of wide range of tumors. |
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| Keywords: | tumor vasoactive intestinal peptide receptor imaging |
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