| 急性肺损伤肺泡巨噬细胞诱生型一氧化氮合成酶的免疫组化研究 |
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| 引用本文： | 梁延杰 Chi.,EY.急性肺损伤肺泡巨噬细胞诱生型一氧化氮合成酶的免疫组化研究[J].解放军医学杂志,1997,22(3):172-173. |
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| 作者姓名： | 梁延杰 Chi. EY |
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| 作者单位： | 解放军第３０４医院(梁延杰)，美国华盛顿大学医学院(ＥｍｉｌＹＣｈｉ) |
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| 摘 要： | 对大鼠用导管经颈外静脉入右心房持续灌注内毒素（ＬＰＳ），观察肺组织学改变及肺泡巨噬细胞诱生型一氧化氮合成酶（ｉＮＯＳ）免疫组化改变，发现大鼠灌注ＬＰＳ后，于１２，２４及４８ｈ出现逐渐加重的急性肺损伤改变，且肺泡巨噬细胞ｉＮＯＳ阳性表达数目逐渐增多；至７２ｈ，急性肺损伤改变减轻与肺泡巨噬细胞ｉＮＯＳ阳性表达数减少，表明生肺损伤病变程度与ｉＮＯＳ阳性表达数呈平行关系，提示ｉＮＯＳ在急性肺损伤发病机制中
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| 关 键 词： | 肺损伤 急性 肺泡巨噬细胞 一氧化氮合成酶 |
IMMUNOHISTOCHEMICAL STUDY OF iNOS IN ALVEOLAR MACROPHAGES IN ACUTE LUNG INJURY |
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| Liang Yanjie,Emil Y Chi.IMMUNOHISTOCHEMICAL STUDY OF iNOS IN ALVEOLAR MACROPHAGES IN ACUTE LUNG INJURY[J].Medical Journal of Chinese People's Liberation Army,1997,22(3):172-173. |
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| Authors: | Liang Yanjie Emil Y Chi |
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| Institution: | Liang Yanjie,Emil Y Chi.The 304th Hospital of PLA,Beijing 100037 |
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| Abstract: | Immunohistochemical change of inducible nitric oxide synthase(iNOS) was observed in alveolar macrophages in acute lung injury (ALI) of rats induced by continuous intravenous infusion of LPS.We found that the ALI gradually severe as time went on, and the number of alveolar macrophages with positive expression of iNOS gradually increased at 12h, 24h and 48h after LPS. But ALI attenuated, and the number of alveolar macrophages with positive expression of iNOS obviously decreased at 72h.Above data indicate that the number of macrophages with positive expression of iNOS is corresponding to the degree of change in ALI, which suggests that the iNOS may play an important role in the mechanism of ALI. |
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| Keywords: | lung diseases wounds and injuries nitric oxide |
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