Expression of cell surface Friend virus gp70 does not block reinfection by ecotropic murine leukemia viruses |
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| Authors: | B Chesebro J K Collins K Wehrly J Nishio M Cloyd |
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| Affiliation: | U. S. Department of Health and Human Services, Public Health Service, National Institutes of Health, National Institute of Allergy and Infectious Diseases, Laboratory of Persistent Viral Diseases, Rocky Mountain Laboratories, Hamilton, Montana 59840, USA |
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| Abstract: | The effect of cell surface gp70 expression on reinfection by murine leukemia virus was studied in Friend virus (FV)-induced erythroleukemia cell clones. A clone (2C) which released gp70-positive infectious virions and expressed large amounts of cell surface ecotropic FV gp70 was not superinfectable by ecotropic viruses, whereas another clone (7C) which expressed similar amounts of cell surface FV gp70 but released gp70-deficient virions showed no resistance to superinfection. The lack of interference to superinfection of 7C cells suggested that newly budded gp70-positive virions, rather than cell surface gp70 molecules, were responsible for the interference to superinfection seen in 2C cells which released infectious virus. |
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| Keywords: | To whom reprint requests should be addressed. |
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