| 新平喘药—α-萜品烯醇的药理作用 |
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| 引用本文： | 卞如濂,周汉良,谢强敏,魏尔清,唐法娣. 新平喘药—α-萜品烯醇的药理作用[J]. 中国药理学通报, 1987, 0(6) |
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| 作者姓名： | 卞如濂 周汉良 谢强敏 魏尔清 唐法娣 |
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| 作者单位： | 浙江医科大学平喘药研究室 杭州(卞如濂，周汉良，谢强敏，魏尔清)，浙江医科大学平喘药研究室 杭州(唐法娣) |
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| 摘 要： | 艾叶油平喘成分α-萜品烯醇在豚鼠整体和离体实验中具有气道松弛作用,能升高气管平滑肌内cAMP含量,还有抗过敏、镇咳和祛痰作用,并且毒性低,为一安全有效的新平喘药。本品不同于β受体激动剂,对豚鼠离体心房具有抑制作用。
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| 关 键 词： | α-萜品烯醇 豚鼠 气管平滑肌 平喘 |
THE PHARMACOLOGICAL PROPERTIES OF A NEW ANTIASTHMATIC DRUG, a-TERPINEOL |
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| BiSn Rulian,Zhou Hanliang,Xie Qiangmin,Wei Erqin,et al. THE PHARMACOLOGICAL PROPERTIES OF A NEW ANTIASTHMATIC DRUG, a-TERPINEOL[J]. Chinese Pharmacological Bulletin, 1987, 0(6) |
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| Authors: | BiSn Rulian Zhou Hanliang Xie Qiangmin Wei Erqin et al |
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| Abstract: | a-Terpineol as an another antiasthmatic principle of essential oil of Artemisia argyi was studied. It had relaxant effect on isolated guinea pig tracheal smooth muscle preparations, the effective threshold concentrations being between 2. l-4.2x10-5 g/ml, and the EC50 being 0.71-1.15x10-4g/ml. It could protect guinea pigs from the acetylcholine and histamine-induced asthma when given orally or aer-osolly. The level of cAMP in the tracheal smooth muscle of guinea pigs was elevated in the presence of l0-4g/ml a- terpineol. The drug could block the development of desensitization to isoproterenol on isolated guinea pig tracheal smooth muscle preparations, and its relaxant effect did not be- influenced on the desensitized preparations also. In addition, a-terpineol had the Inhibitory effect of anaphylactic mediators release antagonistic effect of the mediators, antitussive and expectorant effect, and the inhibitory effect on isolated ed guinea pig atria. The toxiicological studies showed that it had good safety margin. ( + ) - a-Terpineol amd (-) a -terpineol had similarquality and potency of actions. |
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| Keywords: | a-Terpineol new antiasthmatic artemisia argyi relaxant tracheal smooth muscle guinea pig |
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