| Implications of Cytogenetic Abnormalities and Azoospermia Factor Microdeletions in Assisted Procreation |
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| 引用本文： | Rima Dada R Kumar M Bilal Shamsi Sarabpreet Singh Col R K Sharma A Varshney. Implications of Cytogenetic Abnormalities and Azoospermia Factor Microdeletions in Assisted Procreation[J]. 生殖与避孕(英文版), 2007, 18(3): 231-235. DOI: 10.1016/S1001-7844(07)60028-5 |
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| 作者姓名： | Rima Dada R Kumar M Bilal Shamsi Sarabpreet Singh Col R K Sharma A Varshney |
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| 作者单位： | Laboratory of Molecular Reproduction and Genetics Department of Anatomy，AIIMS N Delhi 110029 India，Laboratory of Molecular Reproduction and Genetics Department of Anatomy，AIIMS N Delhi 110029 India，Laboratory of Molecular Reproduction and Genetics Department of Anatomy，AIIMS N Delhi 110029 India，Anatomy Department AIIMS，N Delhi 110029 India，ART centre Obstretics and Gynaecology Department Army Research and Referral hospital，New Delhi India，AIIMS，N Delhi 110029 India |
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| 摘 要： | Assisted procreation techniques have revolutionized the management of infertility and have offered hope to millions of infertile couples. The main aim of these proce- dures is to produce healthy offspring. However recent studies on short term outcome of ART have reported a higher incidence of low birth weight, development delay, imprinting defects, sex and autosomal structural abnormalities, major and minor congenital malformation and certain cancers in babies conceived via ART. Further the health of ART conceived children beyond the neonatal period have been less well evaluated. A large number of infertile couples opting for ART have an underlying genetic aetiology. These genetic aberrations are iatrogenitically transmitted via ART. Thus it is important that all couples undergo a detailed and comprehensive genetic evaluation prior to ART.
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| 关 键 词： | 遗传学 染色体变异 不育症 治疗方法 |
| 收稿时间： | 2007-05-05 |
| 修稿时间： | 2007-05-05 |
Implications of Cytogenetic Abnormalities and Azoospermia Factor Microdeletions in Assisted procreation |
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| Rima Dada,R Kumar,M Bilal Shamsi,Sarabpreet Singh,Col R K Sharma,A Varshney. Implications of Cytogenetic Abnormalities and Azoospermia Factor Microdeletions in Assisted procreation[J]. Journal of Reproduction and Contraception, 2007, 18(3): 231-235. DOI: 10.1016/S1001-7844(07)60028-5 |
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| Authors: | Rima Dada R Kumar M Bilal Shamsi Sarabpreet Singh Col R K Sharma A Varshney |
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| Affiliation: | Rima Dada(Laboratory of Molecular Reproduction and Genetics, Department of Anatomy, AIIMS, N Delhi, 110029, India)；R Kumar(Laboratory of Molecular Reproduction and Genetics, Department of Anatomy, AIIMS, N Delhi, 110029, India)；M Bilal Shamsi(Laboratory of Molecular Reproduction and Genetics, Department of Anatomy, AIIMS, N Delhi, 110029, India)；Sarabpreet Singh(Anatomy Department, AIIMS, N Delhi, 110029, India)；Col R K Sharma(ART centre, Obstretics and Gynaecology Department, Army Research and Referral hospital. New Delhi, India)；A Varshney(AIIMS, N Delhi, 110029, India)； |
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| Abstract: | Assisted procreation techniques have revolutionized the management of infertility and have offered hope to millions of infertile couples. The main aim of these proce- dures is to produce healthy offspring. However recent studies on short term outcome of ART have reported a higher incidence of low birth weight, development delay, imprinting defects, sex and autosomal structural abnormalities, major and minor congenital malformation and certain cancers in babies conceived via ART. Further the health of ART conceived children beyond the neonatal period have been less well evaluated. A large number of infertile couples opting for ART have an underlying genetic aetiology. These genetic aberrations are iatrogenitically transmitted via ART. Thus it is important that all couples undergo a detailed and comprehensive genetic evaluation prior to ART. |
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| Keywords: | genetics chromosomal abnormality AZF Yq microdeletion assisted reproduction ART |
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