2型糖尿病患者脑局部一致性的静息态功能MRI

目的 应用静息态功能MR（rs-fMRI）的局部一致性（ReHo）技术探讨2型糖尿病（T2DM）患者的静息态脑部功能的变化特点。方法 对48例T2DM患者（T2DM组）及40名年龄、性别、受教育水平相匹配的健康对照组行常规MRI及rs-fMRI检查，计算全脑ReHo值并进行组内和组间比较，提取存在显著差异脑区的ReHo值并与临床数据做相关分析。结果 与对照组比较，T2DM组左右舌回/距状皮层、左右颞上回、左侧小脑半球的ReHo值降低；而右侧楔前叶、左侧额上回/额中回及岛叶ReHo值升高。左右舌回/距状皮层平均ReHo值与体质量指数（r=-0.420，P=0.003）、数字连接试验B（r=-0.504，P=0.001）呈负相关，与Rey-osterrich复杂图形测试（r=0.686，P=0.001）呈正相关。结论 T2DM患者静息态多个脑区ReHo值降低或升高，提示这些脑区神经功能紊乱，可能是患者认知功能障碍的影像学基础。

Regional homogeneity in patients with type 2 diabetes using resting-state functional MRI

Objective To explore functional brain changes in type 2 diabetes mellitus (T2DM) patients by analyzing the regional homogeneity (ReHo) values of the brain with resting-state fMRI (rs-fMRI). Methods T2DM patients (n=48) and age-, sex-, and education-matched healthy controls (n=40) were underwnt conventional MRI and rs-fMRI. ReHo values were calculated and compared in intra-group and inter-group. Then correlation analysis were conducted between ReHo values with significant difference and clinical data of T2DM patients. Results Compared with healthy controls, T2DM patients showed significantly decreased ReHo values in bilateral lingual gyrus/calcarine cortex, bilateral superior temporal gyrus, and left cerebellar hemisphere, while increased ReHo values in right precuneus, left superior frontal gyrus/middle frontal gyrus and insula. Furthermore, the ReHo values of lingual gyrus/calcarine cortex were inversely correlated with the body mass index (r=-0.420, P=0.003) and TMT-B (r=-0.504, P=0.001), and positively correlated with Rey-osterrich complex figure test (r=0.686, P=0.001) in T2DM patients. Conclusion The ReHo values were decreased or increased in multiple brain regions of T2DM patients, suggesting abnormal spontaneous activity in those regions. It probably indicates that ReHo values may be used as an objective approach to evaluate potential cognitive impairment in T2DM patients.