苦参碱及其制剂的研究进展

苦参碱是从中药苦参中分离得到的天然产物，临床上主要用于慢性病毒性肝炎的治疗。目前主流的苦参碱制剂类型包括注射剂、栓剂、胶囊剂和片剂，处于研发状态的剂型有靶向制剂、缓控释制剂和透皮吸收制剂。对临床常用的苦参碱制剂进行科学的优化和新剂型的研发，可以显著性提高苦参碱的生物利用度。药物新剂型的研发和新材料的应用，可以扩大苦参碱制剂的临床应用，从而增强苦参碱制剂的临床疗效。这些对中药单体化合物苦参碱的研究及其制剂的开发具有积极作用。基于以上研究，笔者对苦参碱药理活性、制备方法和制剂的研究情况做一总结，以期为今后苦参碱的开发到其制剂的研究提供参考。

A Research Progress on Matrine and Its Preparations

Matrine is an effective natural product isolated from the traditional herb,Sophora flavescens,with wide range of pharmacological and clinical effects and treating as the treatment for chronic viral hepatitis in clinic.Currently,the mainstream clinical preparations of matrine involved injections,tablets,capsules and suppositories,while preparations under development included targeting preparations,sustained-release preparations and transdermal drug delivery preparations.Admittedly,It can significantly improve the biological utilization of matrine through the optimization of its clinical preparations for with scientific researches and the development of new dosage forms.While the clinical applications will be expanded and the clinical efficacy of the preparations of matrine enhanced with the development of researches for new dosage forms and drugs and the application of new materials.It may be also benefical to the study of monomer compositions of Chinese material medica,including the development of the preparation of matrine.Rested on the recent studies, pharmacological activities, preparation methods and researches for the preparations of matrine was summarized in this text for providing a reference for developing its preparations in the future.