雷公藤内酯软膏对银屑病皮损ICAM-1、MMP-9表达的影响

目的了解银屑病患者皮损中ICAM-1、MMP-9表达水平及分布,并比较雷公藤内酯对银屑病皮损I-CAM-1、MMP-9的表达的影响,讨论其临床意义。方法采用免疫组化法和染色评分半定量法对15例进行期银屑病皮损标本和10例对照组标本中ICAM-1、MMP-9的表达量进行检测,比较结果。同时与雷公藤内酯治疗有效的银屑病患者的消退期皮损的皮损ICAM-1、MMP-9的表达量比较。结果进行期银屑病皮损ICAM-1、MMP-9的表达量明显高于对照组。两组间差异有显著性(P<0.05)。雷公藤内酯治疗有效的银屑病患者的消退期皮损的皮损ICAM-1、MMP-9的表达量与进行期皮损相比明显降低,两组间差异有显著性(P<0.05)。结论进行期银屑病皮损ICAM-1、MMP-9表达增高且与疾病严重度密切相关,雷公藤内酯可抑制银屑病皮损ICAM-1、MMP-9的表达,雷公藤内酯对银屑病的治疗作用可能与其抑制ICAM-1、MMP-9的表达有关。

Effects of Triperygium Wilfordii Oitment on Expression of Intercelluar Adhesion Molecule-1 and Matrix Metallo proteinase-9 in Psoriatic Lesion

Objective To study the expression and distribution of intercellular adhesion molecule-1(ICAM-1) and matrix metalloproteinase-9(MMP-9) in psoriatic lesions and the effects of triperygium wilfordii on them. Methods 15 experimental specimens and 15 controls were examined with the immunohistochemical assay. Results There was a significant difference between the control and experimental groups (P<0.05). There was an obvious decrease of ICAM-1 and MMP-9 in psoriatic lesion after the treatment with triperygium wilfordii. Conclusion The expression of ICAM-1 and MMP-9 was enhanced in psoriatic lesion,and there was a significant correlation between them. Both of them might cooperatively advance the proceeding of psoriasis.