冠心病患者心率变异性分析

目的研究冠心病患者心率变异（HRV）的变化规律及临床意义。方法选择50例无心律失常冠心病患者（冠心病组）、30例伴心律失常冠心病患者（心率失常组）与52例正常成人自愿者（正常组）进行24h动态心电图HRV指标比较研究。结果与正常组比较，冠心病患者SDNN、SDANN、RMSSD、PNN50和HF指标均降低，LF指标升高，具有显著差异。伴心律失常与无心律失常冠心病患者比较，HRV指标异常变化趋于恶化。结论冠心病患者心脏自主神经调节功能受到损害，迷走神经活性减弱，交感神经活动占优势。

Analysis of heart rate variability in patients with coronary heart disease

Objective To study the variation and clinical significance of heart rate variability （HRV） in patients with coronary heart disease. Methods Totally 50 coronary heart disease patients without arrhythmia （ coronary heart disease group） , 30 coronary heart disease patients with arrhythmia （arrhythmia group） and 52 normal persons （control group） were enrolled. The 24-hours dynamic electrocardiograph HRV indicator comparison was made between the three groups. Results The indicators of HRV time domain analysis were： SDNN, SDANN, RMSSD,PNNS0, HF and LF. The indicators of SDNN, SDANN, RMSSD, PNNS0 and HF were lower and the indicator of HF was higher in coronary heart disease group and arrhythmia group compared with those in control group, with significant differences. The abnormal changes of HRV indicators were worsen in arrhythmia group compared with those in coronary heart disease group. Conclusion In patients with coronary heart disease, the regulatory function of the cardiac autonomic nerve is damaged, the activity of the vagus nerve is decreased and the sympathetic nerve activity is dominant.