| 碱和水份对7-氯-6-氟-4-羟基喹啉-3-羧酸乙酯的N-或O-乙基化产物比例的影响 |
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| 引用本文： | 郭惠元,孙兰英,曹一尘,田治明. 碱和水份对7-氯-6-氟-4-羟基喹啉-3-羧酸乙酯的N-或O-乙基化产物比例的影响[J]. 中国医药工业杂志, 1993, 0(7) |
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| 作者姓名： | 郭惠元 孙兰英 曹一尘 田治明 |
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| 作者单位： | 中国医学科学院医药生物技术研究所 北京100050 |
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| 摘 要： | 7-氯-6-氟-4-羟基喹啉-3-羧酸乙酯(3)的乙基化使用无水 K_2CO_3或无水 Na_2CO_3作脱酸剂,用HPLC 法测定 N-及 O-乙基化物(2与1)的相对含量。考察了溶剂中水份对2和1生成比例的影响。
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| 关 键 词： | 诺氟沙星 合成中间体 喹啉衍生物 |
EFFECT OF DIFFERENT BASES AND HYDROUS SOLVENT ON RATIO OF N-AND O-ETHYLATED PRODUCTS OF ETHYL 7-CHLORO-6-FLUORO-4-HYDROXYQUINoUNE 3-CARBOXYLATE |
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| GUO Hui-Yuan SUN Lan-Ying CAO Yi-Cheng TIAN Zhi-Ming. EFFECT OF DIFFERENT BASES AND HYDROUS SOLVENT ON RATIO OF N-AND O-ETHYLATED PRODUCTS OF ETHYL 7-CHLORO-6-FLUORO-4-HYDROXYQUINoUNE 3-CARBOXYLATE[J]. , 1993, 0(7) |
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| Authors: | GUO Hui-Yuan SUN Lan-Ying CAO Yi-Cheng TIAN Zhi-Ming |
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| Abstract: | Ethyl 7-chloro-6-fluoro-4-hydroxyquinoline-3-carboxylate (3) wassubjected to ethylation with ethyl bromide in different solvents (including hydrousDMF) with anhydrous K_2CO_3 or Na_CO_3 to give mixed N-and O-ethylated pro-ducts(2 and 1).The ratio betwean 2 and 1 in the mixture was investigated byHPLC method.The result indicated that the relative content of 1 was signifi-cantly reduced with Na_2CO_3 and not affected by the water contained in DMF. |
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| Keywords: | norfloxacin synthesis intermediate quinoline derivative |
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