基于因子分析与聚类分析的老年溃疡性结肠炎中医证候特点研究

目的 :探讨老年溃疡性结肠炎中医证素特点及证型分类、分布规律。方法 :采集206例老年溃疡性结肠炎患者的四诊信息,运用因子分析与聚类分析相结合的方法对35项变量进行分析,结合证素辨证体系寻找本病的中医证素特点及证型分布规律。结果:证素辨证学研究得出本组206例老年溃疡性结肠炎病位证素5项,病性证素9项,其中病位证素主要涉及脾、肠、肾、肝,病性证素主要涉及气虚、湿、热、阳虚、寒、气滞;采用因子分析35个证候条目,结合证素辨证学及专家讨论,总结出6类中医证型:大肠湿热证、脾胃气虚证、脾肾阳虚证、肝郁脾虚证、阴虚肠燥证、血瘀肠络证;采用聚类分析得出上述证型的分布比例,依次为脾胃气虚证28.16%(58/206)、大肠湿热证23.30%(48/206)、脾肾阳虚证21.84%(45/206)、肝郁脾虚证13.11%(27/206)、阴虚肠燥证8.74%(18/206)、血瘀肠络证4.85%(10/206)。结论:老年溃疡性结肠炎基本中医证型有六类,以气虚证、湿热证、阳虚证最常见。

Study on Characteristics of Traditional Chinese Medicine Syndromes of Senile Ulcerative Colitis Based on Factor Analysis and Cluster Analysis

Objective:To explore the characteristics of traditional Chinese medicine(TCM) syndrome elements of senile ulcerative colitis and the classification and distribution regularities of its syndrome types. Methods:The four kinds of diagnostic information were collected from 206 cases of senile ulcerative colitis patients.The characteristics of TCM syndrome elements and the distribution regularities of syndrome types were analyzed by factor analysis method and cluster analysis method. The two methods were combined to analyze the35 variables and syndrome differentiation system. Results:The syndrome differentiation study showed that there were 5 syndrome elements of disease location and 9 syndrome elements of disease nature in the 206 cases of ulcerative colitis. The syndrome elements of disease location mainly involved the spleen,intestine,kidney and liver,and the disease nature mainly involved qi deficiency,dampness,heat,deficiency of yang,cold and qi stagnation. The factor analysis method was used to analyze the 35 syndrome entries. Based on syndrome differentiation and expert discussion,6 types of TCM syndrome were summarized,including damp heat in large intestine syndrome,spleen and stomach qi deficiency syndrome,spleen and kidney yang deficiency syndrome,liver stagnation and spleen deficiency syndrome,yin deficiency and intestinal dryness syndrome,blood stasis in intestinal collaterals syndrome. The syndromes distribution proportion were analyzed by cluster analysis method:spleen and stomach qi deficiency syndrome 28.16%(58/206),damp heat in large intestine syndrome 23.30%(48/206),spleen and kidney yang deficiency syndrome 21.84%(45/206),liver stagnation and spleen deficiency syndrome 13.11%(27/206),yin deficiency and intestinal dryness syndrome 8.74%(18/206),blood stasis in intestinal collaterals syndrome 4.85%(10/206). Conclusion:There were 6 basic TCM syndrome types of senile ulcerative colitis,in which the qi deficiency syndrome,damp heat syndrome,yang deficiency syndrome are the common types.