芪黄疽愈方对糖尿病肢体动脉闭塞症踝肱指数及跛行指数的影响

目的 :观察芪黄疽愈方对糖尿病肢体动脉闭塞症(diabetic limb arterial obliteration,DLAO)患者踝肱指数、跛行指数及跛行距离的影响。方法:将160例DLAO患者按随机数字表法分为治疗组和对照组各80例。在使用常规降糖药物和前列地尔注射液的基础上,治疗组应用芪黄疽愈方治疗,对照组应用西药西洛他唑治疗。观察两组治疗前后踝肱指数、跛行指数、跛行距离及不良反应情况。结果:治疗后两组踝肱指数、跛行指数、跛行距离较治疗前均显著提高,差异有统计学意义(P0.05),且治疗组提高更明显,与对照组比较,差异有统计学意义(P0.05)。两组均无明显不良反应。结论:西洛他唑和芪黄疽愈方均可有效改善患者肢体血液循环,芪黄疽愈方较西洛他唑疗效更佳,安全性良好。

Effect of Qihuang Juyu Formula on Ankle-Brachial Index and Claudication Index of Diabetic Limb Arterial Obliteration

Objective:To observe the effect of Qihuang Juyu formula on ankle-brachial index,claudication index and claudication distance of patients with diabetic limb arterial obliteration(DLAO). Methods:A total of160 patients with DLAO were randomly divided into treatment group and control group according to the random number table. Each group had 80 patients. On the basis of routine use of hypoglycemic drugs and alprostadil,the treatment group was given Qihuang Juyu formula and the control group was given western medicine cilostazol. The ankle-brachial index,claudication index,claudication distance and adverse reaction of the two groups were observed before and after treatment. Results:After treatment,the ankle-brachial index,claudication index and claudication distance of the two groups were significantly increased,which were statistically different from those before treatment(P<0.05). The increase of the treatment group was more signifi cant than that of the control group and the difference was statistically significant(P<0.05). There were no obvious adverse reactions in the two groups. Conclusion:Both cilostazol and Qihuang Juyu formula can effectively improve the limbs blood circulation of the patients,but the effect of Qihuang Juyu formula was better and safer than that of cilostazol.