小半夏汤对化疗小鼠胃排空和小肠推进异常的改善作用

目的 :观察小半夏汤对正常小鼠和化疗模型小鼠胃残留率和小肠推进率的影响,从胃肠动力角度初步探讨小半夏汤防治化疗性恶心呕吐的机制。方法:小半夏汤给正常小鼠连续灌胃给药7 d后,灌胃营养性半固体糊,测定胃残留率和小肠推进率;小半夏汤连续给小鼠灌胃7 d,从灌胃第4天起腹腔注射顺铂2 mg/kg,连续注射4 d,灌胃营养性半固体糊,测定胃残留率和小肠推进率。结果:小半夏汤对正常小鼠胃残留率和小肠推进率均无明显影响(P0.05)。与正常对照组比较,顺铂模型小鼠胃残留率显著升高(P0.01),小肠推进率显著加快(P0.001);小半夏汤高剂量可使模型动物胃残留率显著降低(P0.01),小半夏汤中、低剂量有使胃残留率降低的趋势,但无统计学意义;小半夏汤低、中剂量可显著抑制模型动物小肠推进亢进(分别P0.001、P0.05),而大剂量只有抑制趋势(P0.05)。结论 :小半夏汤对正常生理状态小鼠的胃排空和小肠推进无明显影响;对顺铂所致的胃排空延缓和小肠推进亢进具有显著改善作用。

Effect of Xiaobanxia Decoction on Gastric Emptying and Small Intestinal Propulsion in Mice after Chemotherapy

Objective:To observe the effect of Xiaobanxia decoction on gastric residual rate and small intestinal propulsion rate in normal mice and mice after chemotherapy,and to explore its mechanism of preventing and treating chemotherapy induced nausea and vomiting from gastrointestinal motility. Methods:Normal mice were given Xiaobanxia decoction by gavage for 7 days,and the mice were given nutritional semi-solid paste to determine the gastric residual rate and intestinal propulsive rate;Mice after chemotherapy were given Xiaobanxia decoction by gavage for 7 days,on the 4th day,mice were given intraperitoneal injection of cisplatin,2 mg/kg,for 4 days continuously,and the mice were also given nutritional semi-solid paste to determine gastric residual rate and intestinal propulsive rate. Results:Xiaobanxia decoction had no effect on gastric residual rate and small intestinal propulsion rate in normal mice. Compared with the normal control group,the gastric residual rate of cisplatin model significantly increased(P<0.01),and the small intestine propulsion rate also significantly increased(P<0.001);compared with cisplatin group,Xiaobanxia decoction of high dose could reduce the gastric residual rate significantly(P<0.01),Xiaobanxia decoction of medium dose and low dose could reduce the gastric residual rate,without statistical significance(P> 0.05);compared with cisplatin group,Xiaobanxia decoction of low dose and medium dose could significantly inhibit the intestinal propulsive hyperfunction(P <0.001 and P <0.05,respectively),but high dose only showed inhibitory trend(P> 0.05). Conclusion:Xiaobanxia decoction had no significant effect on gastric emptying and small intestine propulsion in normal mice,but it could significantly relieve the gastric emptying delay and small intestinal propulsion hyperfunction induced by cisplatin.