新加二仙汤治疗老年高血压伴焦虑状态临床研究

目的:观察新加二仙汤治疗老年高血压伴焦虑状态的疗效及安全性。方法:95例确诊为老年高血压伴焦虑状态的患者按随机数字表法分为新加二仙汤组49例和拜新同组46例。拜新同组单纯使用拜新同片治疗,新加二仙汤组在服用拜新同片的基础上加用新加二仙汤,两组均连续治疗4周。治疗前后测量患者血压,统计患者中医临床证候评价量表、焦虑自评量表(SAS)评分,评价中医证候及降压疗效。结果:新加二仙汤组降压总有效率83.67%,高于拜新同组的65.22%,但差异无统计学意义(P0.05);与拜新同组比较,新加二仙汤组舒张压降低更明显。新加二仙汤组的中医证候评分较治疗前明显降低,差异有统计学意义(P0.01);新加二仙汤组中医证候疗效明显优于拜新同组,差异有统计学意义(P0.05)。与治疗前比较,新加二仙汤组治疗后的SAS评分明显降低,差异有统计学意义(P0.01);拜新同组无明显变化,差异无统计学意义(P0.05)。两组治疗期间均未出现明显不良反应。结论:新加二仙汤合用拜新同片能有效降低患者血压,且降低舒张压的效果更明显,可改善患者临床症状,缓解其焦虑情绪,有助于从多方面提高患者的生活质量。

Clinical Study of Treating Senile Hypertension with Anxiety Status with Modified Erxian Decoction

Objective:To observe the curative effects and safety of modified Erxian decoction on senile hypertension with anxiety status. Methods:A total of 95 patients diagnosed as senile hypertension with anxiety status were divided into two groups by the random number table method,the modified Erxian decoction group containing 49 patients and the Adalat GITS group containing 46 patients. The Adalat GITS group was only treated with Adalat GITS,while the modified Erxian decoction group,based on Adalat GITS,was treated with modified Erxian decoction. Both the two groups were treated continuously for 4 weeks. The blood pressure,traditional Chinese medicine(TCM) clinical syndrome evaluation scale scores and self-rating anxiety scale(SAS) scores were evaluated before and after treatment,and the curative effects on reducing blood pressure and TCM syndromes were assessed repectively. Results:The total antihypertensive effective rate of the modified Erxian decoction group was 83.67%,which was higher than that of the Adalat GITS group(65.22%),but the difference was not statistically significant(P> 0.05). Compared with the Adalat GITS group,the decrease of diastolic blood pressure in the modified Erxian decoction group was more obvious. Compared with those before treatment,the scores of TCM syndromes of the modified Erxian decoction group was significantly decreased and the difference was statistically significant(P<0.01). The curative effect of TCM syndrome of the modified Erxian decoction group was better than that of the Adalat GITS group,and the difference was statistically significant(P<0.05). Compared with that before treatment,the SAS score was significantly reduced in the modified Erxian decoction group and the difference was statistically significant(P<0.01),while there was no significant change in the Adalat GITS group and the difference was not statistically significant(P> 0.05). During the treatment,there were no significant adverse reactions in the two groups. Conclusion:Modified Erxian decoction combined with Adalat GITS can effectively reduce the patients'blood pressure,especially the diastolic blood pressure,improve the clinical symptoms and ease patients' anxiety. It helps to improve the life quality of the patients in several ways.