腰突颗粒治疗气滞血瘀及肝肾亏虚型腰椎间盘突出症疗效对比研究

目的 :对比研究腰突颗粒治疗气滞血瘀型和肝肾亏虚型腰椎间盘突出症的临床疗效。方法 :选取腰椎间盘突出症患者270例,A组90例为气滞血瘀证型,B组90例为肝肾亏虚证型,C组90例未予中医辨证。A、B两组均口服腰突颗粒煎煮剂,每次服用20 m L,日2次;C组口服双氯芬酸钠双释放肠溶胶囊,一次75 mg,日2次。三组均以10 d为一疗程,持续服药2疗程。服药前、服药1疗程后、服药2疗程后分别对三组患者进行疼痛视觉模拟评分(VAS)和Oswestry功能障碍指数(ODI)评价。服药2疗程后参照《中医病证诊断疗效标准》进行疗效评价。结果 :三组治疗1、2疗程后VAS评分、ODI指数均降低,与治疗前比较,差异有统计学意义(P0.05);A组治疗1、2疗程后的VAS评分、ODI指数明显低于B、C两组,差异有统计学意义(P0.05)。A组临床总有效率和治愈率均优于其他两组,差异有统计学意义(P0.05)。结论:腰突颗粒对气滞血瘀型腰椎间盘突出症的疗效优于肝肾亏虚型。

Comparative Study of Clinical Effects Of Yaotu Capsule on Lumbar Disc Herniation of Liver and Kidney Insufficiency Syndrome and Qi Stagnation and Blood Stasis Syndrome

Objective:To comparatively investigate the clinical effect of Yaotu capsule on lumbar disc herniation of liver and kidney deficiency syndrome and qi stagnation and blood stasis syndrome. Methods:A total of 270 patients with lumbar disc herniation were selected as the study objects. Patients in group A(n=90)were diagnosed as liver and kidney deficiency syndrome. Patients in group B(n=90) were diagnosed as qi stagnation and blood stasis syndrome. The rest 90 patients in group C were not given syndrome differentiation. Patients in group A and group B were given the decoction of Yaotu capsule for oral administration,20 m L a time,2 times a day. Patients in group C were given oral diclofenac sodium dual release enteric-coated capsule for oral administration,75 mg a time,2 times a day. All the 3 groups took 10 days as a course and the treatment continued for 2 courses. The pain visual analogue scale(VAS) score and oswestry disability index(ODI) of the 3 groups were evaluated before treatment,1 course after treatment and 2 courses after treatment respectively. Two courses after treatment,the clinical effect of the 3 groups were evaluated according to Standards for Diagnosis and Curative Effect of Traditional Chinese Medicine Disease and Syndrome.Results:Both 1 course and 2 courses after treatment,the VAS score and ODI of the 3 groups were decreased,which were statistically different from those before treatment(P<0.05). Furthermore,the VAS score and ODI of group A were lower than those of the other two groups and the difference were statistically significant(P<0.05). The curative rate and effective rate of group A were better than those of the other two groups and the difference were statistically significant(P <0.05). Conclusion :The curative effect of Yaotu capsule on lumbar disc herniation of qi stagnation and blood stasis syndrome was better than that on liver and kidney deficiency syndrome.