胡荫奇补肾活血法对强直性脊柱炎血栓弹力图的影响

目的 :观察胡荫奇补肾活血法对活动期强直性脊柱炎(AS)的疗效并探讨血栓弹力图(TEG)与AS病情活动度的关系。方法:确诊的150例AS患者随机分为对照组(75例),口服柳氮磺吡啶肠溶片、洛索洛芬钠片;试验组(75例)在西药基础上加用补肾活血方。观察治疗前后两组晨僵时间、外周关节疼痛数、Schober试验、胸廓活动度、枕-墙距、指-地距、红细胞沉降率(ESR)、C-反应蛋白(CRP)、TEG。结果:治疗后试验组有效率优于对照组(P<0.05),两组患者除胸廓活动度无明显变化外,其余均较治疗前明显改善(P<0.05),且试验组改善优于对照组(P<0.05);同时TEG中的凝血反应时间(R)、最大振幅(MA)与ESR、CRP存在正相关关系(P<0.01)。结论 :补肾活血法联合西药治疗活动期强直性脊柱炎优于西药治疗,且TEG与强直性脊柱炎病情活动相关。

Effects of HU Yinqi's Tonifying Kidney and Promoting Blood Circulation Method on Thromboela-stogram of Ankylosing Spondylitis

Objective:To observe the clinical effects of HU Yinqi's tonifying the kidney and promoting blood circulation method in treatment of ankylosing spondylitis(AS) at active stage and to investigate the correlation between thromboela-stogram(TEG) and pathogenetic activity of ankylosing spondylitis. Methods :Totally150 patients with AS at active stage were randomly divided into the treatment group(75 patients) and control group(75 patients). Both groups were treated with sulfasalazine and loxoprofen sodium tablets,and the treatment group was given Bushen Huoxue decoction additionally. Twelve-week treatment was one course.The clinical changes such as morning stiffness,joint pain and function,erythrocyte sedimentation rate(ESR),C-reactive protein(CRP),TEG and adverse reactions were observed. Results:In the treatment group,the total effective rate was 89.3%,superior to that in the control group(84%),with a significant difference(P< 0.05).Compared with that before treatment,only the occiput-wall distance of both groups remained unchanged,other clinical and laboratory indices of both groups were improved(P< 0.05). There was a significant positive correlation among R and MA of TEG,ESR and CRP(P< 0.01). Conclusion:The tonifying the kidney and promoting blood circulation method combined with western medicine in treatment of ankylosing spondylitis(AS) at active stage was more effective than western medicine treatment and TEG has a correlation with disease activity of ankylosing spondylitis.