| IL-6对弓形虫增殖的影响 |
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| 引用本文： | 方艳秋,谭岩,张永生,李敬. IL-6对弓形虫增殖的影响[J]. 中国寄生虫学与寄生虫病杂志, 1999, 17(2): 106-108 |
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| 作者姓名： | 方艳秋 谭岩 张永生 李敬 |
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| 作者单位： | 白求恩医科大学一院中心实验室,白求恩医科大学基础寄生虫教研室,武警吉林省总队５支队卫生队 |
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| 摘 要： | 目的：观察白细胞介素－６（ＩＬ－６）对弓形虫增殖的影响。方法：以Ｃ５７ＢＬ／６小鼠腹腔巨噬细胞为靶细胞,采用３Ｈ－尿嘧啶（３Ｈ－Ｕ）特异性标记的弓形虫在ＭΦ内的增殖实验。结果：单独应用ＩＬ－６处理ＭΦ,可以促进弓形虫在ＭΦ内的增殖,α肿瘤坏死因子（ＴＮＦα）的影响不明显;而在ＩＬ－６逆转γ干扰素（ＩＦＮγ）诱导的ＭΦ抗弓形虫效应的实验中发现,加入抗ＴＮＦα抗体可增加ＩＬ－６对ＩＦＮγ诱导ＭΦ抗弓形虫效应的逆转作用。结论：体外应用ＩＬ－６可促进弓形虫在小鼠腹腔ＭΦ内的增殖作用,并能部分逆转ＩＦＮγ的抗弓形虫效应。
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| 关 键 词： | 弓形虫 白细胞介素－6 γ干扰素 α肿瘤坏死因子 |
EFFECT OF IL 6 ON THE MULTIPLICATION OF TOXOPLASMA GONDII |
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| FANG Yanqiu,TAN Yan,ZHANG Yongsheng,LI Jing. EFFECT OF IL 6 ON THE MULTIPLICATION OF TOXOPLASMA GONDII[J]. Chinese Journal of Parasitology and Parasitic Diseases, 1999, 17(2): 106-108 |
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| Authors: | FANG Yanqiu TAN Yan ZHANG Yongsheng LI Jing |
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| Affiliation: | Central Lab., First Teaching Hospital, Bethune University of Medical Sciences, Changchun 130021. |
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| Abstract: | AIM: To observe the effect of IL-6 on the multiplication of Toxoplasma gondii. METHODS: Peritoneal macrophages from C57BL/6 mouse were incubated with 3H-uracil-labelled T. gondii in vitro. RESULTS: Pretreatment (but not post-treatment) of Mphi with IL-6 enhanced T. gondii multiplication in a dose-dependent manner. Pretreatment with IFN gamma resulted in active killing of parasites whereas the addition of IL-6 resulted in a partial reversal of IFN gamma-mediated toxoplasmacidal activity. Combining TNF alpha with IL-6 and IFN gamma pretreatment resulted in restoration of toxoplasmacidal activity. Addition of polyclonal anti-TNF alpha antibodies to IL-6 and IFN gamma pretreatment resulted in enhancement in the IL-6-mediated impairment of IFN gamma function. CONCLUSION: IL-6 could enhance intraperitoneal multiplication of T. gondii and reverse IFN gamma-mediated toxoplasmacidal activity. |
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| Keywords: | Toxoplasma gondii')" >Toxoplasma gondii IL 6 IFNγ ')" >TNFα |
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