静脉推注硫代硫酸钠与葡萄糖酸钙不良反应发生情况的比较研究

目的 对比2种药物静脉推注(简称静推)不良反应发生率、不良反应临床表现、严重程度及静推时间,为临床安全用药提供依据.方法 选取2009年6月至2010年6月以过敏性疾病就诊的患者共200例,按就诊日期单、双日随机分为硫代硫酸钠组和葡萄糖酸钙组各100例.比较2组患者不良反应发生率、不良反应临床表现及严重程度、平均静推时间.结果 与葡萄糖酸钙相比,静推硫代硫酸钠不良反应发生率较低,平均静推时间较短,且无严重不良反应发生.结论 静推硫代硫酸钠不良反应发生率低、静推时间较短,且较少发生严重不良反应,值得临床推广使用.

Abstract：

Objective To compare the incidence of adverse reaction,clinical manifestation and serious degree of adverse reaction and the intravenous injection time of the two different drugs,and provide references for the safe dosage of the drugs in clinic.Methods 200 patients from June 2009 to June 2010,who visited department of dermatology because of allergic dermatitis were chosen.They were randomly divided into the sodium thiosulfate group and the calcium gluconate group according to the drugs which were injected intravenouly.And incidence of adverse reaction,clinical manifestation and serious degree of adverse reaction and the intravenous injection time were compared between two groups.Results Compared with the calcium gluconate group,the rate of the adverse reaction of the sodium thiosulfate group is lower,and the average time needed is shorter,in addition,there is no serious adverse reaction during injection.Conclusions Intravenous injection of sodium thiosulfate has the advantage of lower incidence of adverse reaction,shorter time needed,and fewer serious adverse reaction,which is worthy of wide spread.

Comparative research on the adverse reaction of the intravenous injection of sodium thiosulfate and calcium gluconate

Objective To compare the incidence of adverse reaction,clinical manifestation and serious degree of adverse reaction and the intravenous injection time of the two different drugs,and provide references for the safe dosage of the drugs in clinic.Methods 200 patients from June 2009 to June 2010,who visited department of dermatology because of allergic dermatitis were chosen.They were randomly divided into the sodium thiosulfate group and the calcium gluconate group according to the drugs which were injected intravenouly.And incidence of adverse reaction,clinical manifestation and serious degree of adverse reaction and the intravenous injection time were compared between two groups.Results Compared with the calcium gluconate group,the rate of the adverse reaction of the sodium thiosulfate group is lower,and the average time needed is shorter,in addition,there is no serious adverse reaction during injection.Conclusions Intravenous injection of sodium thiosulfate has the advantage of lower incidence of adverse reaction,shorter time needed,and fewer serious adverse reaction,which is worthy of wide spread.