| Relationship between matrix metalloproteinase-9 polymorphism and acute coronary syndrome |
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| 作者姓名： | Linlin Wang Tiebing Zhu Yong Li |
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| 作者单位： | Department of Cardiology, the First Affiliated Hospital of Nanjing Medical University, Nanjing 210029, China |
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| 摘 要： | Objective： To investigate the relationship of matrix metalloproteinase-9 polymorphism to acute coronary syndrome and its affect on the severity of coronary artery disease. Methods： By means of polymerase chain reaction （PCR） and restriction fragment length polymorphism, genotypes of 245 patients with acute coronary syndrome（ACS） and 205 healthy subjects were tested. Genotypes displaying C-1562T functional promoter polymorphism （of the MMP-9 gene） were determined. The relationship between the polymorphism of the MMP-9 gene and ACS and the severity of coronary vessels diseased was analyzed. Results： The frequency of C/T plus T/T genotypes and T allele in patients with ACS was significantly higher than that in healthy subjects （22.1% vs 12.7% and 11.4% vs 6.6% respectively）. But they were not associated with the number of coronary arteries diseased. Conclusion： The MMP-9 polymorphism may be susceptible to ACS. But there was not significant difference between the AMI and UAP subgroups.
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| 关 键 词： | 基质金属蛋白酶-9 多态性 急性冠脉综合怔 相关性 |
| 收稿时间： | 2007/12/18 0:00:00 |
Relationship between matrix metalloproteinase-9 polymorphism and acute coronary syndrome |
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| Linlin Wang,Tiebing Zhu,Yong Li.Relationship between matrix metalloproteinase-9 polymorphism and acute coronary syndrome[J].Acta Universitatis Medicinalis Nanjing,2007,21(3):147-150. |
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| Authors: | Linlin Wang Tiebing Zhu and Yong Li |
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| Institution: | Department of Cardiology, the First Affiliated Hospital of Nanjing Medical University, Nanjing 210029,China |
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| Abstract: | Objective: To investigate the relationship of matrix metalloproteinase-9 polymorphism to acute coronary syndrome and its affect on the severity of coronary artery disease. Methods: By means of polymerase chain reaction (PCR) and restriction fragment length polymorphism, genotypes of 245 patients with acute coronary syndrome(ACS) and 205 healthy subjects were tested. Genotypes displaying C-1562T functional promoter polymorphism (of the MMP-9 gene) were determined. The relationship between the polymorphism of the MMP-9 gene and ACS and the severity of coronary vessels diseased was analyzed. Results: The frequency of C/T plus T/T genotypes and T allele in patients with ACS was significantly higher than that in healthy subjects (22.1% vs 12.7% and 11.4% vs 6.6% respectively). But they were not associated with the number of coronary arteries diseased. Conclusion:The MMP-9 polymorphism may be susceptible to ACS. But there was not significant difference between the AMI and UAP subgroups. |
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| Keywords: | matrix metalloproteinases(MMP) polymorphism acute coronary syndrome acute coronary syndrome polymorphism matrix significant difference subgroups susceptible associated number arteries allele plus frequency Results coronary vessels gene functional promoter healthy genotypes |
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